tetrapyrrole biosynthesis II (from glycine)

Heinemann IU, Jahn M, Jahn D. The biochemistry of heme biosynthesis. Archives of Biochemistry and Biophysics. 2008 Jun;474(2):238–51. doi: 10.1016/j.abb.2008.02.015.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Diacetyl

Formula: C4H6O2 (86.0367776)

CAS ID: 431-03-8

Diethyl pyrocarbonate

Formula: C6H10O5 (162.052821)

CAS ID: 1609-47-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen cyanide

Formula: CHN (27.010898599999997)

CAS ID: 74-90-8

Iodine

Formula: I2 (253.808954)

CAS ID: 7553-56-2

Lithium

Formula: Li (7.016005)

CAS ID: 7439-93-2

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Mercury(2+)

Formula: Hg (201.970632)

CAS ID: 14302-87-5

N-Ethylmaleimide

Formula: C6H7NO2 (125.0476762)

CAS ID: 128-53-0

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Pyridoxal

Formula: C8H9NO3 (167.0582404)

CAS ID: 66-72-8

Rubidium cation

Formula: Rb (84.9118)

CAS ID: 22537-38-8

iodoacetamide

Formula: C2H4INO (184.9337644)

CAS ID: 144-48-9

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.37 5-aminolevulinate synthase succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
2.5.1.61 hydroxymethylbilane synthase porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
4.2.1.24 porphobilinogen synthase 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
4.2.1.75 uroporphyrinogen-III synthase hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)


Proteins

Protein ID name full name
P42504 hemB Delta-aminolevulinic acid dehydratase
Q06965 hemT 5-aminolevulinate synthase 2