sphingolipid biosynthesis (plants)

Tonon T, Sayanova O, Michaelson LV, Qing R, Harvey D, Larson TR, Li Y, Napier JA, Graham IA. Fatty acid desaturases from the microalga Thalassiosira pseudonana. The FEBS Journal. 2005 Jun 24;272(13):3401–12. doi: 10.1111/j.1742-4658.2005.04755.x.; Kwalombota M. The effect of pregnancy in HIV-infected women. AIDS Care. 2002 Jun;14(3):431–3. doi: 10.1080/09540120220123829. PMID: 12042089.; Sperling P, Libisch B, Zähringer U, Napier JA, Heinz E. Functional Identification of a ?8-Sphingolipid Desaturase from Borago officinalis. Archives of Biochemistry and Biophysics. 2001 Apr;388(2):293–8. doi: 10.1006/abbi.2001.2308.; Wallis JG, Browse J. The Delta8-desaturase of Euglena gracilis: an alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids. Arch Biochem Biophys. 1999 May 15;365(2):307–16. doi: 10.1006/abbi.1999.1167. PMID: 10328826.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Dihydroceramide

Formula: C19H39NO3 (329.29297840000004)

CAS ID:

3-dehydrosphinganinium(1+)

Formula: C18H38NO2 (300.2902388)

CAS ID:

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP-alpha-D-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:

cyclo[Ile-N(Me)Val-Leu-N(Me)Val(3-OH)-D-OxiIle-N(Me)Val-Phe-N(Me)Phe-Pro]

Formula: C60H92N8O11 (1100.6885201999999)

CAS ID: 127785-64-2



Enzyme

EC Number name full name note
1.1.1.102 3-dehydrosphinganine reductase D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase
1.14.18.5 sphingolipid C4-monooxygenase dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)
1.14.18.7 dihydroceramide fatty acyl 2-hydroxylase dihydroceramide,ferrocytochrome-b5:oxygen oxidoreductase (fatty acyl 2-hydroxylating)
1.14.19.17 sphingolipid 4-desaturase dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (4,5-dehydrogenating)
1.14.19.29 sphingolipid 8-(E/Z)-desaturase (4R)-4-hydroxysphinganine ceramide,ferrocytochrome b5:oxygen oxidoreductase (8,9 cis/trans-dehydrogenating)
2.3.1.50 serine C-palmitoyltransferase palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
2.7.1.138 ceramide kinase ATP:ceramide 1-phosphotransferase
2.7.1.227 inositol phosphorylceramide synthase 1-phosphatidyl-1D-myo-inositol:a very-long-chain (2'R)-2'-hydroxy-phytoceramide phosphoinositoltransferase
2.7.1.91 sphingosine kinase ATP:sphingoid base 1-phosphotransferase


Proteins

Protein ID name full name