NAD salvage pathway V (PNC V cycle)
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Manipulation of a Nuclear NAD+ Salvage Pathway Delays Aging without Altering Steady-state NAD+ Levels. Journal of Biological Chemistry. 2002 May;277(21):18881–90. doi: 10.1074/jbc.m111773200.; Jackson MD, Denu JM. Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases. J Biol Chem. 2002 May 24;277(21):18535–44. doi: 10.1074/jbc.m200671200. PMID: 11893743.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.3.1.286 | protein acetyllysine N-acetyltransferase | [protein]-N6-acetyl-L-lysine:NAD+ N-acetyltransferase (NAD+-hydrolysing; 2''-O-acetyl-ADP-D-ribose-forming) | |
| 2.7.7.1 | nicotinamide-nucleotide adenylyltransferase | ATP:nicotinamide-nucleotide adenylyltransferase | |
| 2.7.7.18 | nicotinate-nucleotide adenylyltransferase | ATP:nicotinate-ribonucleotide adenylyltransferase | |
| 3.5.1.19 | nicotinamidase | nicotinamide amidohydrolase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P06700 | SIR2 | NAD-dependent histone deacetylase SIR2 |
| P53184 | PNC1 | Nicotinamidase |
| P53204 | NMA2 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 |
| Q06178 | NMA1 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 |