superpathway of NAD biosynthesis in eukaryotes

Jackson MD, Denu JM. Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases. J Biol Chem. 2002 May 24;277(21):18535–44. doi: 10.1074/jbc.m200671200. PMID: 11893743.; Panozzo C, Nawara M, Suski C, Kucharczyk R, Skoneczny M, Bécam A, Rytka J, Herbert CJ. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Letters. 2002 Mar 22;517(1-3):97–102. doi: 10.1016/s0014-5793(02)02585-1.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Formylkynurenine

Formula: C11H12N2O4 (236.07970319999998)

CAS ID: 1022-31-7

Mercury(2+)

Formula: Hg (201.970632)

CAS ID: 14302-87-5

Nickel(2+)

Formula: Ni (57.935347)

CAS ID: 14701-22-5

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

Nicotinamide-beta-riboside

Formula: C11H15N2O5 (255.098092)

CAS ID: 1341-23-7

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

nicotinate

Formula: C6H4NO2 (122.0242024)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

deamido-NAD(2-)

Formula: C21H24N6O15P2 (662.0774854)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

2''-O-acetyl-ADP-D-ribose(2-)

Formula: C17H23N5O15P2 (599.0665868000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.13.11.52 indoleamine 2,3-dioxygenase D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)
1.14.13.9 kynurenine 3-monooxygenase L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2.3.1.286 protein acetyllysine N-acetyltransferase [protein]-N6-acetyl-L-lysine:NAD+ N-acetyltransferase (NAD+-hydrolysing; 2''-O-acetyl-ADP-D-ribose-forming)
2.4.2.19 nicotinate-nucleotide diphosphorylase (carboxylating) nicotinate-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)
2.6.1.7 kynurenine-oxoglutarate transaminase L-kynurenine:2-oxoglutarate aminotransferase
2.7.1.173 nicotinate riboside kinase ATP:beta-D-ribosylnicotinate 5-phosphotransferase
2.7.1.22 ribosylnicotinamide kinase ATP:N-ribosylnicotinamide 5'-phosphotransferase
2.7.7.1 nicotinamide-nucleotide adenylyltransferase ATP:nicotinamide-nucleotide adenylyltransferase
2.7.7.18 nicotinate-nucleotide adenylyltransferase ATP:nicotinate-ribonucleotide adenylyltransferase
3.5.1.19 nicotinamidase nicotinamide amidohydrolase
3.7.1.3 kynureninase L-kynurenine hydrolase


Proteins

Protein ID name full name
P06700 SIR2 NAD-dependent histone deacetylase SIR2
P38169 BNA4 Kynurenine 3-monooxygenase
P43619 BNA6 Nicotinate-nucleotide pyrophosphorylase [carboxylating]
P47039 BNA3 Probable kynurenine--oxoglutarate transaminase BNA3
P47096 BNA1 3-hydroxyanthranilate 3,4-dioxygenase
P47125 BNA2 Indoleamine 2,3-dioxygenase
P53184 PNC1 Nicotinamidase
P53204 NMA2 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
P53915 NRK1 Nicotinamide riboside kinase
Q05979 BNA5 Kynureninase
Q06178 NMA1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1