L-lysine biosynthesis II

Devenish SR, Blunt JW, Gerrard JA. NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase. J Med Chem. 2010 Jun 24;53(12):4808–12. doi: 10.1021/jm100349s. PMID: 20503968.; Weinberger S, Gilvarg C. Bacterial Distribution of the Use of Succinyl and Acetyl Blocking Groups in Diaminopimelic Acid Biosynthesis. J Bacteriol. 1970 Jan;101(1):323–4. doi: 10.1128/jb.101.1.323-324.1970.; Farkas W, Gilvarg C. The Reduction Step in Diaminopimelic Acid Biosynthesis. Journal of Biological Chemistry. 1965 Dec;240(12):4717–22. doi: 10.1016/s0021-9258(18)97014-6.

Metabolites

1,10-Phenanthroline

Formula: C12H8N2 (180.0687448)

CAS ID: 66-71-7

Cadmium

Formula: Cd (113.903361)

CAS ID: 7440-43-9

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Dimercaprol

Formula: C3H8OS2 (124.00165580000001)

CAS ID: 59-52-9

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

meso-2,6-Diaminoheptanedioate

Formula: C7H14N2O4 (190.0953524)

CAS ID: 922-54-3

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

(4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate

Formula: C7H7NO5 (185.0324212)

CAS ID:

(S)-2,3,4,5-tetrahydrodipicolinate

Formula: C7H7NO4 (169.0375062)

CAS ID:

N-acetyl-LL-2,6-diaminopimelate(1-)

Formula: C9H15N2O5 (231.098092)

CAS ID:

(S)-2-acetamido-6-oxopimelate(2-)

Formula: C9H11NO6 (229.0586346)

CAS ID:

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

dipicolinate(2-)

Formula: C7H3NO4 (165.0062078)

CAS ID:

L-aspartate(1-)

Formula: C4H6NO4 (132.0296816)

CAS ID:

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

4-phosphonato-L-aspartic acid(2-)

Formula: C4H6NO7P (210.98818959999997)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:

L-lysinium(1+)

Formula: C6H15N2O2 (147.113347)

CAS ID: 56-87-1



Enzyme

EC Number name full name note
1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase
1.2.1.11 aspartate-semialdehyde dehydrogenase L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
2.7.2.4 aspartate kinase ATP:L-aspartate 4-phosphotransferase
4.1.1.20 diaminopimelate decarboxylase meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)


Proteins

Protein ID name full name
P08495 lysC Aspartokinase 2
P23630 lysA Diaminopimelate decarboxylase
P42976 dapB 4-hydroxy-tetrahydrodipicolinate reductase
P94417 yclM Aspartokinase 3
Q04797 asd Aspartate-semialdehyde dehydrogenase