superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis
Dai N, Petreikov M, Portnoy V, Katzir N, Pharr DM, Schaffer AA. Cloning and expression analysis of a UDP-galactose/glucose pyrophosphorylase from melon fruit provides evidence for the major metabolic pathway of galactose metabolism in raffinose oligosaccharide metabolizing plants. Plant Physiol. 2006 Sep;142(1):294–304. PMID: 16829585; PMCID: PMC1557607.; Samuel G, Reeves P. Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly. Carbohydr Res. 2003 Nov 14;338(23):2503–19. doi: 10.1016/j.carres.2003.07.009. PMID: 14670712.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.22 | UDP-glucose 6-dehydrogenase | UDP-alpha-D-glucose:NAD+ 6-oxidoreductase | |
| 2.7.7.9 | UTP-glucose-1-phosphate uridylyltransferase | UTP:alpha-D-glucose-1-phosphate uridylyltransferase | |
| 5.1.3.2 | UDP-glucose 4-epimerase | UDP-glucose 4-epimerase | |
| 5.4.2.2 | phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) | alpha-D-glucose 1,6-phosphomutase | |
| 5.4.99.9 | UDP-galactopyranose mutase | UDP-D-galactopyranose furanomutase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P09147 | galE | UDP-glucose 4-epimerase |
| P0AEP3 | galU | UTP--glucose-1-phosphate uridylyltransferase |
| P21977 | galE | UDP-glucose 4-epimerase |
| P36938 | pgm | Phosphoglucomutase |
| P37747 | glf | UDP-galactopyranose mutase |
| P76373 | ugd | UDP-glucose 6-dehydrogenase |
| P9WIQ1 | glf | UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) |
| P9WN67 | galE1 | UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) |
| Q57346 | cap3A | UDP-glucose 6-dehydrogenase |