superpathway of seleno-compound metabolism

Lyi SM, Zhou X, Kochian LV, Li L. Biochemical and molecular characterization of the homocysteine S-methyltransferase from broccoli (Brassica oleracea var. italica). Phytochemistry. 2007 Apr;68(8):1112–9. doi: 10.1016/j.phytochem.2007.02.007. PMID: 17391716.; Sors TG, Ellis DR, Salt DE. Selenium uptake, translocation, assimilation and metabolic fate in plants. Photosynth Res. 2005 Dec;86(3):373–89. doi: 10.1007/s11120-005-5222-9. PMID: 16307305.; Sors TG, Ellis DR, Na GN, Lahner B, Lee S, Leustek T, Pickering IJ, Salt DE. Analysis of sulfur and selenium assimilation in Astragalus plants with varying capacities to accumulate selenium. The Plant Journal. 2005 May 05;42(6):785–97. doi: 10.1111/j.1365-313x.2005.02413.x.; Lyi SM, Heller LI, Rutzke M, Welch RM, Kochian LV, Li L. Molecular and biochemical characterization of the selenocysteine Se-methyltransferase gene and Se-methylselenocysteine synthesis in broccoli. Plant Physiol. 2005 May;138(1):409–20. PMID: 15863700; PMCID: PMC1104194.; Tagmount A, Berken A, Terry N. An Essential Role ofS-Adenosyl-l-Methionine:l-MethionineS-Methyltransferase in Selenium Volatilization by Plants. Methylation of Selenomethionine to Selenium-Methyl-l-Selenium- Methionine, the Precursor of Volatile Selenium. 2002 Oct 01;130(2):847–56. doi: 10.1104/pp.001693.; Zhou ZS, Smith AE, Matthews RG. l-selenohomocysteine: one-step synthesis from l-selenomethionine and kinetic analysis as substrate for methionine synthases. Bioorganic & Medicinal Chemistry Letters. 2000 Nov;10(21):2471–5. doi: 10.1016/s0960-894x(00)00498-4.; Terry N, Zayed AM, de Souza MP, Tarun AS. SELENIUM INHIGHERPLANTS. Annu. Rev. Plant. Physiol. Plant. Mol. Biol. 2000 Jun;51(1):401–32. doi: 10.1146/annurev.arplant.51.1.401.; de Souza MP, Lytle CM, Mulholland MM, Otte ML, Terry N. Selenium assimilation and volatilization from dimethylselenoniopropionate by Indian mustard. Plant Physiol. 2000 Apr;122(4):1281–8. PMID: 10759525; PMCID: PMC58964.; Pilon-Smits EAH, Hwang S, Mel Lytle C, Zhu Y, Tai JC, Bravo RC, Chen Y, Leustek T, Terry N. Overexpression of ATP Sulfurylase in Indian Mustard Leads to Increased Selenate Uptake, Reduction, and Tolerance1. 1999 Jan 01;119(1):123–32. doi: 10.1104/pp.119.1.123.; Turner RJ, Weiner JH, Taylor DE. Selenium metabolism in Escherichia coli. Biometals. 1998 Sep;11(3):223–7. doi: 10.1023/a:1009290213301. PMID: 9850565.; Burnell JN. Selenium Metabolism in Neptunia amplexicaulis. Plant Physiol. 1981 Feb 01;67(2):316–24. doi: 10.1104/pp.67.2.316.; Dilworth GL, Bandurski RS. Activation of selenate by adenosine 5'-triphosphate sulphurylase from Saccharomyces cerevisiae. Biochem J. 1977 Jun 01;163(3):521–9. PMID: 328009; PMCID: PMC1164733.; Hsieh HS, Ganther HE. Acid-volatile selenium formation catalyzed by glutathione reductase. Biochemistry. 1975 Apr 22;14(8):1632–6. doi: 10.1021/bi00679a014. PMID: 235962.; Shaw WH, Anderson JW. Purification, properties and substrate specificity of adenosine triphosphate sulphurylase from spinach leaf tissue. Biochem J. 1972 Mar;127(1):237–47. PMID: 5073745; PMCID: PMC1178578.

Metabolites

Acetate

Formula: C2H4O2 (60.0211284)

CAS ID: 64-19-7

Adenylylselenate

Formula: C10H14N5O10PSe (474.9643484)

CAS ID: 90120-86-8

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Dimethyl selenide

Formula: C2H6Se (109.9634686)

CAS ID: 593-79-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Selenite

Formula: H2O3Se (129.9169152)

CAS ID: 14124-67-5

Dimethyl diselenide

Formula: C2H6Se2 (189.87998960000002)

CAS ID: 7101-31-7

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

acrylate

Formula: C3H3O2 (71.0133038)

CAS ID: 10344-93-1

selenate

Formula: O4Se (143.896181)

CAS ID: 14124-68-6

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

Phytochelatin

Formula: C10H16N3O6S- (306.0759776)

CAS ID: 98726-08-0



Enzyme

EC Number name full name note
2.1.1.12 methionine S-methyltransferase S-adenosyl-L-methionine:L-methionine S-methyltransferase
2.3.1.30 serine O-acetyltransferase acetyl-CoA:L-serine O-acetyltransferase
2.5.1.160 plant cystathionine gamma-synthase O-phospho-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase
2.7.7.4 sulfate adenylyltransferase ATP:sulfate adenylyltransferase
4.4.1.13 cysteine-S-conjugate beta-lyase L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)


Proteins

Protein ID name full name