superpathway of L-threonine metabolism
Epperly BR, Dekker EE. Inactivation of Escherichia coli L-threonine dehydrogenase by 2,3-butanedione. Evidence for a catalytically essential arginine residue. J Biol Chem. 1989 Nov 05;264(31):18296–301. PMID: 2681195.; Boylan SA, Dekker EE. Growth, enzyme levels, and some metabolic properties of an Escherichia coli mutant grown on L-threonine as the sole carbon source. J Bacteriol. 1983 Oct;156(1):273–80. doi: 10.1128/jb.156.1.273-280.1983.; Boylan SA, Dekker EE. L-threonine dehydrogenase. Purification and properties of the homogeneous enzyme from Escherichia coli K-12. Journal of Biological Chemistry. 1981 Feb;256(4):1809–15. doi: 10.1016/s0021-9258(19)69880-7.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.3.1.- | |||
| 1.1.1.1 | alcohol dehydrogenase | alcohol:NAD+ oxidoreductase | |
| 1.1.1.103 | L-threonine 3-dehydrogenase | L-threonine:NAD+ oxidoreductase | |
| 1.1.1.86 | ketol-acid reductoisomerase (NADP+) | (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | |
| 1.2.1.10 | acetaldehyde dehydrogenase (acetylating) | acetaldehyde:NAD+ oxidoreductase (CoA-acetylating) | |
| 1.4.3.21 | primary-amine oxidase | primary-amine:oxygen oxidoreductase (deaminating) | |
| 2.2.1.6 | acetolactate synthase | pyruvate:pyruvate acetaldehydetransferase (decarboxylating) | |
| 2.3.1.29 | glycine C-acetyltransferase | acetyl-CoA:glycine C-acetyltransferase | |
| 2.3.1.54 | formate C-acetyltransferase | acetyl-CoA:formate C-acetyltransferase | |
| 2.3.1.8 | phosphate acetyltransferase | acetyl-CoA:phosphate acetyltransferase | |
| 2.6.1.42 | branched-chain-amino-acid transaminase | branched-chain-amino-acid:2-oxoglutarate aminotransferase | |
| 2.7.2.1 | acetate kinase | ATP:acetate phosphotransferase | |
| 2.7.2.15 | propionate kinase | ATP:propanoate phosphotransferase | |
| 4.1.2.48 | low-specificity L-threonine aldolase | L-threonine/L-allo-threonine acetaldehyde-lyase (glycine-forming) | |
| 4.2.1.9 | dihydroxy-acid dehydratase | 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P00893 | ilvI | Acetolactate synthase isozyme 3 large subunit |
| P00894 | ilvH | Acetolactate synthase isozyme 3 small subunit |
| P05791 | ilvD | Dihydroxy-acid dehydratase |
| P05793 | ilvC | Ketol-acid reductoisomerase (NADP(+)) |
| P07913 | tdh | L-threonine 3-dehydrogenase |
| P09373 | pflB | Formate acetyltransferase 1 |
| P0A6A3 | ackA | Acetate kinase |
| P0A9M8 | pta | Phosphate acetyltransferase |
| P0A9Q7 | adhE | Bifunctional aldehyde-alcohol dehydrogenase AdhE |
| P0AB77 | kbl | 2-amino-3-ketobutyrate coenzyme A ligase |
| P0AB80 | ilvE | Branched-chain-amino-acid aminotransferase |
| P0ADG1 | ilvM | Acetolactate synthase isozyme 2 small subunit |
| P11868 | tdcD | Propionate kinase |
| P37686 | yiaY | Probable alcohol dehydrogenase |
| P42632 | tdcE | PFL-like enzyme TdcE |
| P46883 | tynA | Primary amine oxidase |
| P75823 | ltaE | Low specificity L-threonine aldolase |
| P77580 | mhpF | Acetaldehyde dehydrogenase |