NAD salvage pathway I (PNC VI cycle)

Panozzo C, Nawara M, Suski C, Kucharczyk R, Skoneczny M, Bécam A, Rytka J, Herbert CJ. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. FEBS Letters. 2002 Mar 22;517(1-3):97–102. doi: 10.1016/s0014-5793(02)02585-1.

Metabolites

D-Ribose 5-phosphate

Formula: C5H11O8P (230.0191536)

CAS ID: 4300-28-1

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

nicotinate

Formula: C6H4NO2 (122.0242024)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

deamido-NAD(2-)

Formula: C21H24N6O15P2 (662.0774854)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.5.1.-
2.7.7.18 nicotinate-nucleotide adenylyltransferase ATP:nicotinate-ribonucleotide adenylyltransferase
3.5.1.19 nicotinamidase nicotinamide amidohydrolase
6.3.1.5 NAD+ synthase deamido-NAD+:ammonia ligase (AMP-forming)
6.3.4.21 nicotinate phosphoribosyltransferase 5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming)


Proteins

Protein ID name full name
P0A752 nadD Nicotinate-nucleotide adenylyltransferase
P18133 pncB Nicotinate phosphoribosyltransferase
P18843 nadE NH(3)-dependent NAD(+) synthetase
P21369 pncA Nicotinamidase