superpathway of tetrahydrofolate biosynthesis

Metabolites

7,8-Dihydroneopterin

Formula: C9H13N5O4 (255.0967498)

CAS ID: 1218-98-0

Barium cation

Formula: Ba (137.905236)

CAS ID: 22541-12-4

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

Glycolaldehyde

Formula: C2H4O2 (60.0211284)

CAS ID: 141-46-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Rubidium cation

Formula: Rb (84.9118)

CAS ID: 22537-38-8

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

Trimethoprim

Formula: C14H18N4O3 (290.1378838)

CAS ID: 738-70-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

4-aminobenzoate

Formula: C7H6NO2 (136.0398516)

CAS ID: 2906-28-7

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
3.6.1.-
1.5.1.3 dihydrofolate reductase 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
1.5.1.50 dihydromonapterin reductase 5,6,7,8-tetrahydromonapterin:NADP+ oxidoreductase
2.1.1.45 thymidylate synthase 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
2.5.1.15 dihydropteroate synthase (7,8-dihydropterin-6-yl)methyl diphosphate:4-aminobenzoate 2-amino-4-hydroxy-7,8-dihydropteridine-6-methenyltransferase
2.6.1.21 D-amino-acid transaminase D-alanine:2-oxoglutarate aminotransferase
2.6.1.85 aminodeoxychorismate synthase chorismate:L-glutamine aminotransferase
2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase
3.5.4.16 GTP cyclohydrolase I GTP 7,8-8,9-dihydrolase
3.6.1.22 NAD+ diphosphatase NAD+ phosphohydrolase
3.6.1.55 8-oxo-dGTP diphosphatase 8-oxo-dGTP diphosphohydrolase
3.6.1.67 dihydroneopterin triphosphate diphosphatase 7,8-dihydroneopterin 3'-triphosphate diphosphohydrolase
4.1.2.25 dihydroneopterin aldolase 7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
4.1.3.38 aminodeoxychorismate lyase 4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)
5.1.99.8 7,8-dihydroneopterin epimerase 7,8-dihydroneopterin 2'-epimerase
6.3.2.12 dihydrofolate synthase 7,8-dihydropteroate:L-glutamate ligase (ADP-forming)
6.3.2.17 tetrahydrofolate synthase tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming)


Proteins

Protein ID name full name
P00903 pabA Aminodeoxychorismate synthase component 2
P05041 pabB Aminodeoxychorismate synthase component 1
P08192 folC Dihydrofolate synthase/folylpolyglutamate synthase
P0A6T5 folE GTP cyclohydrolase 1
P0ABQ4 folA Dihydrofolate reductase
P0AC13 folP Dihydropteroate synthase
P0AC16 folB Dihydroneopterin aldolase
P0AFC0 nudB Dihydroneopterin triphosphate diphosphatase
P0AFS3 folM Dihydromonapterin reductase
P26281 folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
P28305 pabC Aminodeoxychorismate lyase
Q9CGE1 ylgG hypothetical protein