tryptophan biosynthesis

Kingsbury JM, Goldstein AL, McCusker JH. Role of Nitrogen and Carbon Transport, Regulation, and Metabolism Genes for Saccharomyces cerevisiae Survival In Vivo. Eukaryot Cell. 2006 May;5(5):816–24. doi: 10.1128/ec.5.5.816-824.2006.; Toyn JH, Gunyuzlu PL, White WH, Thompson LA, Hollis GF. A counterselection for the tryptophan pathway in yeast: 5-fluoroanthranilic acid resistance. Yeast. 2000 Apr;16(6):553–60. doi: 10.1002/(sici)1097-0061(200004)16:6<553::aid-yea554>3.0.co;2-7. PMID: 10790693.; Graf R, Mehmann B, Braus GH. Analysis of feedback-resistant anthranilate synthases from Saccharomyces cerevisiae. J Bacteriol. 1993 Feb;175(4):1061–8. doi: 10.1128/jb.175.4.1061-1068.1993.; Braus GH. Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway. Microbiol Rev. 1991 Sep;55(3):349–70. doi: 10.1128/mr.55.3.349-370.1991.; Zalkin H, Paluh JL, van Cleemput M, Moye WS, Yanofsky C. Nucleotide sequence of Saccharomyces cerevisiae genes TRP2 and TRP3 encoding bifunctional anthranilate synthase: indole-3-glycerol phosphate synthase. Journal of Biological Chemistry. 1984 Mar;259(6):3985–92. doi: 10.1016/s0021-9258(17)43193-0.

Metabolites

Anthranilate

Formula: C7H7NO2 (137.0476762)

CAS ID: 118-92-3

Chorismate

Formula: C10H10O6 (226.04773600000001)

CAS ID: 617-12-9

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Serine

Formula: C3H7NO3 (105.0425912)

CAS ID: 56-45-1

L-Tryptophan

Formula: C11H12N2O2 (204.0898732)

CAS ID: 73-22-3

Pyruvate

Formula: C3H4O3 (88.0160434)

CAS ID: 127-17-3



Enzyme

EC Number name full name note


Proteins

Protein ID name full name