vitamin B6 degradation

Yokochi N, Nishimura S, Yoshikane Y, Ohnishi K, Yagi T. Identification of a new tetrameric pyridoxal 4-dehydrogenase as the second enzyme in the degradation pathway for pyridoxine in a nitrogen-fixing symbiotic bacterium, Mesorhizobium loti. Archives of Biochemistry and Biophysics. 2006 Aug;452(1):1–8. doi: 10.1016/j.abb.2006.06.002.; Burg RW, Rodwell VW, Snell EE. Bacterial Oxidation of Vitamin B6. Journal of Biological Chemistry. 1960 Apr;235(4):1164–9. doi: 10.1016/s0021-9258(18)69498-0.

Metabolites

4-Pyridoxolactone

Formula: C8H7NO3 (165.0425912)

CAS ID: 4753-19-9

5-Pyridoxolactone

Formula: C8H7NO3 (165.0425912)

CAS ID: 4543-56-0

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Mercury(2+)

Formula: Hg (201.970632)

CAS ID: 14302-87-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Pyridoxal

Formula: C8H9NO3 (167.0582404)

CAS ID: 66-72-8

Pyridoxine

Formula: C8H11NO3 (169.0738896)

CAS ID: 65-23-6

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note
1.1.1.107 pyridoxal 4-dehydrogenase pyridoxal:NAD+ 4-oxidoreductase
1.1.99.42 4-pyridoxic acid dehydrogenase 4-pyridoxate:acceptor 5-oxidoreductase
1.2.1.100 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylic acid 5-dehydrogenase 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate:NAD+ 5-oxidoreductase
2.6.1.30 pyridoxamine-pyruvate transaminase pyridoxamine:pyruvate aminotransferase
3.1.1.27 4-pyridoxolactonase 4-pyridoxolactone lactonohydrolase
3.5.1.29 2-(acetamidomethylene)succinate hydrolase 2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)
4.1.1.51 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)


Proteins

Protein ID name full name
Q988B7 pldh-t Pyridoxal 4-dehydrogenase
Q988B8 ppaT Pyridoxamine--pyruvate transaminase
Q988B9 PDLA_RHILO 4-pyridoxolactonase
Q988C8 fhmpcd1 5-formyl-3-hydroxy-2-methylpyridine 4-carboxylate 5-dehydrogenase
Q988C9 padh1 4-pyridoxate dehydrogenase
Q988D0 HMPD_RHILO 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
Q988D4 AAMHY_RHILO 2-(acetamidomethylene)succinate hydrolase