Secondary Metabolites: Valine and L-Leucine Biosynthesis from Pyruvate
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.83 | D-malate dehydrogenase (decarboxylating) | (R)-malate:NAD+ oxidoreductase (decarboxylating) | |
| 1.1.1.85 | 3-isopropylmalate dehydrogenase | (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase | |
| 1.1.1.86 | ketol-acid reductoisomerase (NADP+) | (R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing) | |
| 2.2.1.6 | acetolactate synthase | pyruvate:pyruvate acetaldehydetransferase (decarboxylating) | |
| 2.3.3.13 | 2-isopropylmalate synthase | acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | |
| 2.6.1.42 | branched-chain-amino-acid transaminase | branched-chain-amino-acid:2-oxoglutarate aminotransferase | |
| 4.2.1.33 | 3-isopropylmalate dehydratase | (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming) | |
| 4.2.1.9 | dihydroxy-acid dehydratase | 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P00893 | ilvI | Acetolactate synthase isozyme 3 large subunit |
| P00894 | ilvH | Acetolactate synthase isozyme 3 small subunit |
| P05791 | ilvD | Dihydroxy-acid dehydratase |
| P05793 | ilvC | Ketol-acid reductoisomerase (NADP(+)) |
| P09151 | leuA | 2-isopropylmalate synthase |
| P0A6A6 | leuC | 3-isopropylmalate dehydratase large subunit |
| P0AB80 | ilvE | Branched-chain-amino-acid aminotransferase |
| P30125 | leuB | 3-isopropylmalate dehydrogenase |
| P30126 | leuD | 3-isopropylmalate dehydratase small subunit |
| P76251 | dmlA | D-malate dehydrogenase [decarboxylating] |