Biosynthesis of Siderophore Group Nonribosomal Peptides

Metabolites

2,3-Dihydroxybenzoate

Formula: C7H6O4 (154.0266076)

CAS ID: 303-38-8

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

AMP

Formula: C10H14N5O7P (347.06308240000004)

CAS ID: 61-19-8

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

Chorismate

Formula: C10H10O6 (226.04773600000001)

CAS ID: 617-12-9

Enterochelin

Formula: C30H27N3O15 (669.1442112000001)

CAS ID: 28384-96-5

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Serine

Formula: C3H7NO3 (105.0425912)

CAS ID: 56-45-1

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

Pyruvate

Formula: C3H4O3 (88.0160434)

CAS ID: 127-17-3

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8



Enzyme

EC Number name full name note
2.7.8.-
1.3.1.28 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase (2S,3S)-2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase
3.1.1.108 iron(III)-enterobactin esterase iron(III)-enterobactin hydrolase
3.3.2.1 isochorismatase isochorismate pyruvate-hydrolase
5.4.4.2 isochorismate synthase isochorismate hydroxymutase
6.2.1.71 2,3-dihydroxybenzoate-[aryl-carrier protein] ligase 2,3-dihydroxybenzoate:[aryl-carrier protein] ligase (AMP-forming)
6.2.1.72 L-serine-[L-seryl-carrier protein] ligase L-serine:[L-seryl-carrier protein] ligase (AMP-forming)
6.3.2.14 enterobactin synthase 2,3-dihydroxybenzoate:L-serine ligase
7.2.2.17 ABC-type ferric enterobactin transporter ATP phosphohydrolase (ABC-type, iron(III) enterobactin-importing)


Proteins

Protein ID name full name
P0ADI4 entB Enterobactin synthase component B
P0AEJ2 entC Isochorismate synthase EntC
P10378 entE Enterobactin synthase component E
P11454 entF Enterobactin synthase component F
P13039 fes Iron(III) enterobactin esterase
P15047 entA 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
P19925 entD Enterobactin synthase component D
P23878 fepC Ferric enterobactin transport ATP-binding protein FepC