Ferroptosis

Abdalkader M, Lampinen R, Kanninen KM, Malm TM, Liddell JR. Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration. Front. Neurosci. 2018 Jul 10;12(). doi: 10.3389/fnins.2018.00466.

Metabolites

(R)-Mevalonate

Formula: C6H12O4 (148.0735552)

CAS ID: 17817-88-8

(S)-3-Hydroxy-3-methylglutaryl-CoA

Formula: C27H44N7O20P3S (911.1574614)

CAS ID: 1553-55-5

Acetyl-CoA

Formula: C23H38N7O17P3S (809.1257688000001)

CAS ID: 72-89-9

alpha-Tocopherol

Formula: C29H50O2 (430.38106)

CAS ID: 59-02-9

Arachidonate

Formula: C20H32O2 (304.24021719999996)

CAS ID: 506-32-1

CoA

Formula: C21H36N7O16P3S (767.1152046000001)

CAS ID: 85-61-0

Cysteine

Formula: C3H7NO2S (121.0197482)

CAS ID: 3374-22-9

Erastin

Formula: C30H31ClN4O4 (546.2033716)

CAS ID: 571203-78-6

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Fe3+

Formula: Fe (55.934939)

CAS ID: 7439-89-6

gamma-L-Glutamyl-L-cysteine

Formula: C8H14N2O5S (250.0623394)

CAS ID: 636-58-8

Glutathione

Formula: C10H17N3O6S (307.08380220000004)

CAS ID: 70-18-8

Glutathione disulfide

Formula: C20H32N6O12S2 (612.1519552)

CAS ID: 27025-41-8

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Hydroxyl radical

Formula: OH (17.0027396)

CAS ID: 3352-57-6

L-Glutamine

Formula: C5H10N2O3 (146.069139)

CAS ID: 56-85-9

L-Methionine

Formula: C5H11NO2S (149.0510466)

CAS ID: 63-68-3

RSL3

Formula: C23H21ClN2O5 (440.11389260000004)

CAS ID:

Squalene

Formula: C30H50 (410.39123)

CAS ID: 111-02-4

Sulfasalazine

Formula: C18H14N4O5S (398.06848740000004)

CAS ID: 599-79-1

Ubiquinone-10

Formula: C59H90O4 (862.683874)

CAS ID: 303-98-0

PE(18:0/20:4(5Z,8Z,11Z,14Z))

Formula: C43H78NO8P (767.5464757999999)

CAS ID: 61216-62-4

Sorafenib

Formula: C21H16ClF3N4O3 (464.0862972)

CAS ID: 284461-73-0

(6S)-2-Amino-6-[(1S,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-3H-pteridin-4-one

Formula: C9H15N5O3 (241.11748400000002)

CAS ID: 17528-72-2

PE(18:0/20:4(5Z,8Z,11Z,13E)(15OH[S]))

Formula: C43H78NO9P (783.5413907999999)

CAS ID:

glutamate(1-)

Formula: C5H8NO4 (146.0453308)

CAS ID:

isopentenyl diphosphate(3-)

Formula: C5H9O7P2 (242.9823524)

CAS ID:

FIN56

Formula: C25H31N3O5S2 (517.1705036000001)

CAS ID: 1083162-61-1



Enzyme

EC Number name full name note
1.13.11.-
1.13.11.12 linoleate 13S-lipoxygenase linoleate:oxygen 13-oxidoreductase
1.13.11.31 arachidonate 12-lipoxygenase arachidonate:oxygen 12-oxidoreductase
1.13.11.33 arachidonate 15-lipoxygenase arachidonate:oxygen 15-oxidoreductase


Proteins

Protein ID name full name