ERK1/ERK2 pathway

Kuriakose T, Rada B, Watford WT. Tumor Progression Locus 2-dependent Oxidative Burst Drives Phosphorylation of Extracellular Signal-regulated Kinase during TLR3 and 9 Signaling. Journal of Biological Chemistry. 2014 Dec;289(52):36089–100. doi: 10.1074/jbc.m114.587121.; Roskoski R. ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol Res. 2012 Aug;66(2):105–43. doi: 10.1016/j.phrs.2012.04.005. PMID: 22569528.; Matallanas D, Birtwistle M, Romano D, Zebisch A, Rauch J, von Kriegsheim A, Kolch W. Raf Family Kinases: Old Dogs Have Learned New Tricks. Genes & Cancer. 2011 Mar 01;2(3):232–60. doi: 10.1177/1947601911407323.; Wang J, Whiteman MW, Lian H, Wang G, Singh A, Huang D, Denmark T. A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1. Journal of Biological Chemistry. 2009 Aug;284(32):21412–24. doi: 10.1074/jbc.m109.026013.; Dawson CW, Laverick L, Morris MA, Tramoutanis G, Young LS. Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. J Virol. 2008 Apr;82(7):3654–64. PMID: 18199641; PMCID: PMC2268486.; Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene. 2007 May 14;26(22):3100–12. doi: 10.1038/sj.onc.1210392. PMID: 17496909.; McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene. 2007 May 14;26(22):3113–21. doi: 10.1038/sj.onc.1210394. PMID: 17496910.; Yoon S, Seger R. The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors. 2006 Mar;24(1):21–44. doi: 10.1080/02699050500284218. PMID: 16393692.; Wellbrock C, Karasarides M, Marais R. The RAF proteins take centre stage. Nature Reviews Molecular Cell Biology. 2004 Nov;5(11):875–85. doi: 10.1038/nrm1498.; Awane M, Andres PG, Li DJ, Reinecker HC. NF-kappa B-inducing kinase is a common mediator of IL-17-, TNF-alpha-, and IL-1 beta-induced chemokine promoter activation in intestinal epithelial cells. J Immunol. 1999 May 01;162(9):5337–44. PMID: 10228009.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Diphosphoric acid,P-(3,7,11-trimethyl-2,6,10-dodecatrienyl) ester

Formula: C15H28O7P2 (382.1310198)

CAS ID: 13058-04-3

hexadecanoate

Formula: C16H31O2 (255.2323926)

CAS ID: 143-20-4

palmitoyl-CoA(4-)

Formula: C37H62N7O17P3S (1001.3135592)

CAS ID: 1763-10-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic GMP(1-)

Formula: C10H11N5O7P (344.0396086)

CAS ID:

Palmostatin B

Formula: C23H36O4 (376.2613456)

CAS ID:

Cysmethynil

Formula: C25H32N2O (376.25145019999997)

CAS ID: 851636-83-4



Enzyme

EC Number name full name note
2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase
2.5.1.58 protein farnesyltransferase farnesyl-diphosphate:protein-cysteine farnesyltransferase
2.5.1.59 protein geranylgeranyltransferase type I geranylgeranyl-diphosphate:protein-cysteine geranyltransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.23 [RNA-polymerase]-subunit kinase ATP:[DNA-directed RNA polymerase] phosphotransferase
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.11.25 mitogen-activated protein kinase kinase kinase ATP:protein phosphotransferase (MAPKKKK-activated)
2.7.12.2 mitogen-activated protein kinase kinase ATP:protein phosphotransferase (MAPKKK-activated)
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase
3.4.26.1 intramembrane prenyl-peptidase Rce1
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name