Linoleic acid (LA) metabolism
Kapoor R, Huang YS. Gamma linolenic acid: an antiinflammatory omega-6 fatty acid. Curr Pharm Biotechnol. 2006 Dec;7(6):531–4. doi: 10.2174/138920106779116874. PMID: 17168669.; Leonard AE, Pereira SL, Sprecher H, Huang YS. Elongation of long-chain fatty acids. Prog Lipid Res. 2004 Jan;43(1):36–54. doi: 10.1016/s0163-7827(03)00040-7. PMID: 14636670.; Sprecher H. The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2002 Aug;67(2-3):79–83. doi: 10.1054/plef.2002.0402. PMID: 12324224.; Sprecher H. Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2000 Jul;1486(2-3):219–31. doi: 10.1016/s1388-1981(00)00077-9.; Chilton-Lopez, Surette ME, Swan DD, Fonteh AN, Johnson MM, Chilton FH. Metabolism of ?linolenic acid in human neutrophils. 1996 Apr 15;156(8):2941–7. doi: 10.4049/jimmunol.156.8.2941.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.1.2.- | |||
| 1.14.19.3 | acyl-CoA 6-desaturase | linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase | |
| 1.14.19.44 | acyl-CoA (8-3)-desaturase | DELTA8-acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (5,6-cis-dehydrogenating) | |
| 2.3.1.199 | very-long-chain 3-oxoacyl-CoA synthase | malonyl-CoA:very-long-chain acyl-CoA malonyltransferase (decarboxylating and thioester-hydrolysing) | |
| 6.2.1.15 | arachidonate-CoA ligase | arachidonate:CoA ligase (AMP-forming) | |
| 6.2.1.24 | phytanate-CoA ligase | phytanate:CoA ligase (AMP-forming) | |
| 6.2.1.3 | long-chain-fatty-acid-CoA ligase | long-chain fatty acid:CoA ligase (AMP-forming) |
Proteins
| Protein ID | name | full name |
|---|