Linoleoyl-CoA (BioCAD00000013390)

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Metabolite Card

Formula: C39H66N7O17P3S (1029.3449)
SMILES: CCCCC\C=C/C\C=C/CCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N

Synonyms [en]

linoleoyl-CoA; (9Z,12Z)-Octadecadienoyl-CoA; Linoleoyl coenzyme A; Linoleyl-CoA; 9Z-12Z-octadecadienoyl-CoA; (9Z,12Z)-Octadecadienoyl-Coenzyme A

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Linoleoyl-CoA. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000013390). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Linoleoyl-CoA is the acyl-CoA of linoleic acid found in the human body. It binds to and results in decreased activity of glutathione S-transferase1. It has been proposed that inhibition of mitochondrial adenine nucleotide translocator by long-chain acyl-CoA underlies the mechanism associating obesity and type 2 diabetes. Unsaturated fatty acids play an important role in the prevention of human diseases such as diabetes, obesity, cancer, and neurodegeneration. Their oxidation in vivo by acyl-CoA dehydrogenases (ACADs) catalyze the first step of each cycle of mitochondrial fatty acid beta-oxidation. ACAD-9 had maximal activity with long-chain unsaturated acyl-CoAs as substrates (PMID: 17184976, 16020546).

Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 40757-80-0
  • CAS Registry Number: 40780-14-1
  • CAS Registry Number: 6709-57-5
  • PubChem: 134822643
  • PubChem: 5497112
  • PubChem: 6441626
  • ChEBI: ChEBI:15530
  • HMDB: HMDB0001064
  • HMDB: HMDB0062239
  • HMDB: HMDB01064
  • LipidMaps: LMFA07050060
  • LipidMaps: LMFA07050343
  • KEGG: C02050
  • NCBI MeSH: linoleoyl-coenzyme A
  • RefMet: RM0153892
  • Metlin: METLIN_5977
  • Coconut NaturalProduct: CNP0083643.1

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R03814 1.14.19.3 linoleoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
KEGG:R08177 3.1.2.2 linoleoyl-CoA hydrolase
KEGG:R11000 1.14.14.129 linoleoyl-CoA,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (omega-hydroxylating)
KEGG:R11043 1.14.19.6 oleoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (12,13 cis-dehydrogenating)
KEGG:R12205 1.14.19.- linoleoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (15,16 cis-dehydrogenating)
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-556833 Metabolism of lipids
Reactome:R-CFA-1430728 Metabolism
Reactome:R-CFA-556833 Metabolism of lipids
Reactome:R-DRE-8978868 Fatty acid metabolism
Reactome:R-DRE-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Reactome:R-DDI-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Reactome:R-GGA-8978868 Fatty acid metabolism
Reactome:R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-556833 Metabolism of lipids
Reactome:R-PFA-2046105 Linoleic acid (LA) metabolism
Reactome:R-RNO-8978868 Fatty acid metabolism
Reactome:R-RNO-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Reactome:R-XTR-8978868 Fatty acid metabolism
Reactome:R-BTA-8978868 Fatty acid metabolism
Reactome:R-BTA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Reactome:R-CEL-556833 Metabolism of lipids
Reactome:R-CEL-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Reactome:R-CFA-8978868 Fatty acid metabolism
View All Pathways