Glycogen metabolism

Roach PJ, Depaoli-Roach AA, Hurley TD, Tagliabracci VS. Glycogen and its metabolism: some new developments and old themes. Biochem J. 2012 Feb 01;441(3):763–87. PMID: 22248338; PMCID: PMC4945249.; Agius L. Glucokinase and molecular aspects of liver glycogen metabolism. Biochem J. 2008 Aug 15;414(1):1–18. doi: 10.1042/bj20080595. PMID: 18651836.; Bollen M, Keppens S, Stalmans W. Specific features of glycogen metabolism in the liver. Biochem J. 1998 Nov 15;336 ( Pt 1)():19–31. PMID: 9806880; PMCID: PMC1219837.; Hers HG. The control of glycogen metabolism in the liver. Annu Rev Biochem. 1976;45():167–89. doi: 10.1146/annurev.bi.45.070176.001123. PMID: 183599.; Villar-Palasi C, Larner J. Glycogen metabolism and glycolytic enzymes. Annu Rev Biochem. 1970;39():639–72. doi: 10.1146/annurev.bi.39.070170.003231. PMID: 4320262.; Brown BI, Brown DH, Jeffrey PL. Simultaneous absence of alpha-1,4-glucosidase and alpha-1,6-glucosidase activities (pH 4) in tissues of children with type II glycogen storage disease. Biochemistry. 1970 Mar 17;9(6):1423–8. doi: 10.1021/bi00808a017. PMID: 5264799.

Metabolites

1,5-Anhydro-D-fructose

Formula: C6H10O5 (162.052821)

CAS ID: 75414-43-6

1,5-Anhydro-D-glucitol

Formula: C6H12O5 (164.06847019999998)

CAS ID: 154-58-5

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

D-Glucose

Formula: C6H12O6 (180.0633852)

CAS ID: 50-99-7

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP-alpha-D-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.263 1,5-anhydro-D-fructose reductase 1,5-anhydro-D-glucitol:NADP+ oxidoreductase
2.4.1.1 glycogen phosphorylase (1->4)-alpha-D-glucan:phosphate alpha-D-glucosyltransferase
2.4.1.11 glycogen(starch) synthase UDP-glucose:glycogen 4-alpha-D-glucosyltransferase
2.4.1.18 1,4-alpha-glucan branching enzyme (1->4)-alpha-D-glucan:(1->4)-alpha-D-glucan 6-alpha-D-[(1->4)-alpha-D-glucano]-transferase
2.4.1.186 glycogenin glucosyltransferase UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.19 phosphorylase kinase ATP:phosphorylase-b phosphotransferase
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase
2.7.7.9 UTP-glucose-1-phosphate uridylyltransferase UTP:alpha-D-glucose-1-phosphate uridylyltransferase
3.2.1.20 alpha-glucosidase alpha-D-glucoside glucohydrolase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) alpha-D-glucose 1,6-phosphomutase


Proteins

Protein ID name full name