Diseases associated with glycosylation precursor biosynthesis

Freeze HH, Eklund EA, Ng BG, Patterson MC. Neurological Aspects of Human Glycosylation Disorders. Annu. Rev. Neurosci. 2015 Jul 08;38(1):105–25. doi: 10.1146/annurev-neuro-071714-034019.; Jaeken J, Matthijs G. Congenital disorders of glycosylation: a rapidly expanding disease family. Annu Rev Genomics Hum Genet. 2007;8():261–78. doi: 10.1146/annurev.genom.8.080706.092327. PMID: 17506657.

Metabolites

alpha-D-Galactose 1-phosphate

Formula: C6H13O9P (260.0297178)

CAS ID: 2255-14-3

beta-D-Galactose

Formula: C6H12O6 (180.0633852)

CAS ID: 7296-64-2

Galactose

Formula: C6H12O6 (180.0633852)

CAS ID: 26566-61-0

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP-alpha-D-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

isopentenyl diphosphate(3-)

Formula: C5H9O7P2 (242.9823524)

CAS ID:



Enzyme

EC Number name full name note
2.4.1.83 dolichyl-phosphate beta-D-mannosyltransferase GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase
2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10–55 isopentenyl units)
5.1.3.2 UDP-glucose 4-epimerase UDP-glucose 4-epimerase
5.1.3.7 UDP-N-acetylglucosamine 4-epimerase UDP-N-acetyl-D-glucosamine 4-epimerase


Proteins

Protein ID name full name