2-carboxy-1,4-naphthoquinol biosynthesis

Metabolites



Enzyme

EC Number name full name note
2.2.1.9 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase isochorismate:2-oxoglutarate 4-oxopentanoatetransferase (decarboxylating)
4.1.3.36 1,4-dihydroxy-2-naphthoyl-CoA synthase 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA dehydratase (cyclizing)
4.2.1.113 o-succinylbenzoate synthase (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate hydrolyase (2-succinylbenzoate-forming)
4.2.99.20 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate pyruvate-lyase [(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate-forming]
5.4.4.2 isochorismate synthase isochorismate hydroxymutase
6.2.1.26 O-succinylbenzoate-CoA ligase 2-succinylbenzoate:CoA ligase (AMP-forming)


Proteins

Protein ID name full name
O34514 menC o-succinylbenzoate synthase
P23966 menB 1,4-dihydroxy-2-naphthoyl-CoA synthase
P23970 menD 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
P23971 menE 2-succinylbenzoate--CoA ligase
P23973 menF Isochorismate synthase MenF
P23974 menH Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
P45744 dhbC Isochorismate synthase DhbC