biosynthesis of prostaglandins

Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 2001 Nov 30;294(5548):1871–5. doi: 10.1126/science.294.5548.1871. PMID: 11729303.; Pucci ML, Bao Y, Chan B, Itoh S, Lu R, Copeland NG, Gilbert DJ, Jenkins NA, Schuster VL. Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1999 Sep 01;277(3):R734–41. doi: 10.1152/ajpregu.1999.277.3.r734.; Lu R, Schuster VL. Molecular Cloning of the Gene for the Human Prostaglandin Transporter hPGT: Gene Organization, Promoter Activity, and Chromosomal Localization. Biochemical and Biophysical Research Communications. 1998 May;246(3):805–12. doi: 10.1006/bbrc.1998.8715.; Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL. Identification and characterization of a prostaglandin transporter. Science. 1995 May 12;268(5212):866–9. doi: 10.1126/science.7754369. PMID: 7754369.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

prostaglandin F2alpha(1-)

Formula: C20H33O5 (353.23278680000004)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.-
1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD+ 15-oxidoreductase
1.1.1.232 15-hydroxyicosatetraenoate dehydrogenase (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase
1.14.99.1 prostaglandin-endoperoxide synthase (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
2.5.1.18 glutathione transferase RX:glutathione R-transferase
4.2.1.152 hydroperoxy icosatetraenoate dehydratase hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming)
5.3.99.2 Prostaglandin-D synthase (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
5.3.99.3 prostaglandin-E synthase (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase
5.3.99.4 prostaglandin-I synthase (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
5.3.99.5 thromboxane-A synthase (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase


Proteins

Protein ID name full name