Cellular responses to stimuli

Kültz D. Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol. 2005;67():225–57. doi: 10.1146/annurev.physiol.67.040403.103635. PMID: 15709958.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Glutathione

Formula: C10H17N3O6S (307.08380220000004)

CAS ID: 70-18-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Superoxide

Formula: O2 (31.98983)

CAS ID: 11062-77-4

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

L-argininium(1+)

Formula: C6H15N4O2 (175.119495)

CAS ID: 17806-42-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic AMP(1-)

Formula: C10H11N5O6P (328.0446936)

CAS ID: 62906-31-4

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.8.-.-
1.11.1.24 thioredoxin-dependent peroxiredoxin thioredoxin:hydroperoxide oxidoreductase
1.11.1.6 catalase hydrogen-peroxide:hydrogen-peroxide oxidoreductase
1.15.1.1 superoxide dismutase superoxide:superoxide oxidoreductase
1.6.2.4 NADPH-hemoprotein reductase NADPH:hemoprotein oxidoreductase
1.8.1.7 glutathione-disulfide reductase glutathione:NADP+ oxidoreductase
1.8.98.2 sulfiredoxin peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]
2.3.1.286 protein acetyllysine N-acetyltransferase [protein]-N6-acetyl-L-lysine:NAD+ N-acetyltransferase (NAD+-hydrolysing; 2''-O-acetyl-ADP-D-ribose-forming)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.11 cAMP-dependent protein kinase ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent)
2.7.11.22 cyclin-dependent kinase ATP:cyclin phosphotransferase
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.11.25 mitogen-activated protein kinase kinase kinase ATP:protein phosphotransferase (MAPKKKK-activated)
3.5.1.98 histone deacetylase histone amidohydrolase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)
3.6.4.6 vesicle-fusing ATPase ATP phosphohydrolase (vesicle-fusing)
3.6.5.3 protein-synthesizing GTPase GTP phosphohydrolase (mRNA-translation-assisting)


Proteins

Protein ID name full name
O59824 YME1_SCHPO ATP-dependent zinc metalloprotease YME1 homolog
O74887 tpx1 Peroxiredoxin tpx1
O94363 rhb1 GTP-binding protein rhb1
O94537 ire1 Sensor for unfolded proteins in the ER ire1
O94640 sir2 NAD-dependent histone deacetylase sir2
P04551 cdc2 Cyclin-dependent kinase 1
P22774 ssc1 Iron-sulfur cluster biogenesis chaperone, mitochondrial
P28758 sod1 Superoxide dismutase [Cu-Zn]
P28829 byr2 Protein kinase byr2
P36587 ccr1 NADPH--cytochrome P450 reductase
P36604 bip1 Endoplasmic reticulum chaperone BiP
P40376 pka1 cAMP-dependent protein kinase catalytic subunit
P55306 cta1 Catalase
P56523 clr3 Histone deacetylase clr3
P78965 pgr1 Glutathione reductase
Q09130 tif213 Eukaryotic translation initiation factor 2 subunit gamma
Q09683 rad32 Double-strand break repair protein rad32
Q12701 ksg1 Serine/threonine-protein kinase ksg1
Q12706 psk1 Serine/threonine-protein kinase psk1
Q92398 spm1 Mitogen-activated protein kinase spm1
Q9P3A7 cdc48 Cell division cycle protein 48
Q9P7G4 oma1 Mitochondrial metalloendopeptidase OMA1
Q9UQX0 sod2 Superoxide dismutase [Mn], mitochondrial
Q9URV9 srx1 Sulfiredoxin
Q9UTJ8 rad50 DNA repair protein rad50
Q9UTK4 nup189 Nucleoporin nup189
Q9Y7K2 tor2 Serine/threonine-protein kinase tor2