sir2 - Schizosaccharomyces pombe 972h-
NAD-dependent histone deacetylase sir2
> sir2 - Schizosaccharomyces pombe 972h- [NAD-dependent histone deacetylase sir2]
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统计信息
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Metadata
Organism Source: 284812 - Schizosaccharomyces pombe 972h-
EC Number: 2.3.1.286
Cluster:
Registry Model:
Reactions
| reaction id | name | note |
|---|---|---|
| KEGG:R10633 | C00003 + C01997 + C00001<=>C00153 + C02415 + C20658 + C00080 | NAD+ + Histone N6-acetyl-L-lysine + H2O <=> Nicotinamide + Histone-L-lysine + O-Acetyl-ADP-ribose + H+ |
| KEGG:R10634 | C00003 + C20743 + C00001<=>C00153 + C02188 + C20658 + C00080 | Sirtuin |
| BioCyc:RXN0-7078 | CPD3O-0 + NAD + WATER --> Protein-L-lysine + CPD-14762 + NIACINAMIDE | |
| Rhea:RHEA:43637 | N6-acetyl-L-lysyl-[protein] + NAD+ + H2O => 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein] | |
| Rhea:RHEA:43638 | 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein] => N6-acetyl-L-lysyl-[protein] + NAD+ + H2O | |
| Rhea:RHEA:43639 | N6-acetyl-L-lysyl-[protein] + NAD+ + H2O <=> 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein] | |
| BioCyc:RXN-15025 | Histone-Acetyl-Lysine + NAD + WATER --> Histone-L-lysine + CPD-14762 + NIACINAMIDE |
Pathways
| pathway id | name |
|---|---|
| Reactome:R-SPO-3371453 | Regulation of HSF1-mediated heat shock response |
| Reactome:R-SPO-2262752 | Cellular responses to stress |
| Reactome:R-SPO-8953897 | Cellular responses to stimuli |
| Reactome:R-SPO-3371556 | Cellular response to heat stress |