Synthesis of PC

Henneberry AL, Wright MM, McMaster CR. The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity. Mol Biol Cell. 2002 Sep;13(9):3148–61. PMID: 12221122; PMCID: PMC124149.; Wright MM, McMaster CR. PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1). Lipids. 2002 Jul;37(7):663–72. doi: 10.1007/s11745-002-0947-6. PMID: 12216837.

Metabolites

CDP-choline

Formula: C14H26N4O11P2 (488.10732659999996)

CAS ID: 987-78-0

Choline

Formula: C5H14NO (104.10753340000001)

CAS ID: 62-49-7

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase
2.7.1.32 choline kinase ATP:choline phosphotransferase
2.7.7.15 choline-phosphate cytidylyltransferase CTP:choline-phosphate cytidylyltransferase


Proteins

Protein ID name full name
O74827 cho1 Phosphatidyl-N-methylethanolamine N-methyltransferase
O74975 PCY1_SCHPO Probable choline-phosphate cytidylyltransferase
Q10276 KICH_SCHPO Choline kinase