Synthesis of dolichyl-phosphate

Cantagrel V, Lefeber DJ. From glycosylation disorders to dolichol biosynthesis defects: a new class of metabolic diseases. J of Inher Metab Disea. 2011 Mar 08;34(4):859–67. doi: 10.1007/s10545-011-9301-0.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

isopentenyl diphosphate(3-)

Formula: C5H9O7P2 (242.9823524)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.-.-.-
1.3.1.94 polyprenal reductase dolichal:NADP+ 2,3-oxidoreductase
2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10–55 isopentenyl units)
2.7.1.108 dolichol kinase CTP:dolichol O-phosphotransferase
4.1.1.33 diphosphomevalonate decarboxylase ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)


Proteins

Protein ID name full name
P20048 SEC59 Dolichol kinase
P32377 MVD1 Diphosphomevalonate decarboxylase
P34251 YKK7_YEAST Uncharacterized oxidoreductase YKL107W
P35196 RER2 Dehydrodolichyl diphosphate synthase complex subunit RER2
P40526 DFG10 Polyprenal reductase
Q12063 NUS1 Dehydrodolichyl diphosphate synthase complex subunit NUS1