Methionine salvage pathway

Albers E. Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine. IUBMB Life. 2009 Dec;61(12):1132–42. doi: 10.1002/iub.278. PMID: 19946895.; Pirkov I, Norbeck J, Gustafsson L, Albers E. A complete inventory of all enzymes in the eukaryotic methionine salvage pathway. FEBS J. 2008 Aug;275(16):4111–20. doi: 10.1111/j.1742-4658.2008.06552.x. PMID: 18625006.

Metabolites

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

Formula: C6H10O3S (162.035063)

CAS ID: 746507-19-7

5'-Methylthioadenosine

Formula: C11H15N5O3S (297.089556)

CAS ID: 2457-80-9

Adenine

Formula: C5H5N5 (135.054493)

CAS ID: 73-24-5

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

4-methylthio-2-oxobutanoate

Formula: C5H7O3S (147.0115892)

CAS ID:

S-methyl-5-thio-alpha-D-ribose 1-phosphate(2-)

Formula: C6H11O7PS (257.9963106)

CAS ID:



Enzyme

EC Number name full name note
1.13.11.53 acireductone dioxygenase (Ni2+-requiring) 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)
1.13.11.54 acireductone dioxygenase [iron(II)-requiring] 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)
2.4.2.28 S-methyl-5'-thioadenosine phosphorylase S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
3.1.3.77 acireductone synthase 5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)


Proteins

Protein ID name full name
P32626 UTR4 Enolase-phosphatase E1
Q03677 ADI1 Acireductone dioxygenase
Q07938 MEU1 S-methyl-5'-thioadenosine phosphorylase