4-methylthio-2-oxobutanoate (BioCAD00000466486)

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Metabolite Card

Formula: C5H7O3S (147.0116)
SMILES: CSCCC(=O)C([O-])=O

Synonyms [en]

4-methylthio-2-oxobutanoate; 4-(methylsulfanyl)-2-oxobutanoate; 4-methylsulfanyl-2-oxobutanoate; KMTB; 2-oxomethionine; 2-keto-4-methylthiobutanoate

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

4-methylthio-2-oxobutanoate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000466486). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

The 2-oxo monocarboxylic acid anion derived from 4-methylthio-2-oxobutanoic acid. The major microspecies at pH 7.3, it is formed from L-methionine via the action of methionine transaminase." []

Entity Information

DBLinks

Other DBLinks
  • PubChem: 4584184
  • ChEBI: ChEBI:133493
  • ChEBI: ChEBI:16723
  • KEGG: C01180
  • BioCyc: CPD-479
  • NCBI MeSH: 2-keto-4-methylthiobutyric acid

Class / Ontology

Metabolic Network
ID EC Number Name
BioCyc:RXN-12539 CPD-479 + CPD-12377 --> ETHYLENE-CMPD + CPD-7671 + 2 CARBON-DIOXIDE
BioCyc:R15-RXN 2.6.1.88 MET + 2-Oxo-carboxylates<=>CPD-479 + Amino-Acids-20
BioCyc:RXN-2202 2.3.3.17 CPD-479 + ACETYL-COA + WATER --> 2-2-METHYLTHIOETHYLMALIC-ACID + CO-A + PROTON
BioCyc:RXN-7704 4.1.1.1 PROTON + CPD-479 --> CPD-7036 + CARBON-DIOXIDE
BioCyc:RXN-9753 1.1.1.- CPD-479 + NADPH + PROTON --> CPD-10468 + NADP
BioCyc:2.6.1.41-RXN 2.6.1.41 PYRUVATE + CPD-218<=>L-ALPHA-ALANINE + CPD-479
BioCyc:R147-RXN 1.13.11.54 CPD-85 + OXYGEN-MOLECULE --> PROTON + CPD-479 + FORMATE
BioCyc:RXN-14147 2.6.1.88 MET + 2-KETOGLUTARATE<=>CPD-479 + GLT
BioCyc:RXN-15650 2.6.1.117 GLN + CPD-479<=>2-KETO-GLUTARAMATE + MET
BioCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN 2.6.1.73 GLYOX + MET<=>GLY + CPD-479
BioCyc:RXN-7708 2.6.1.28 methionine--phenylpyruvate transaminase
BioCyc:RXN-14685 2.6.1.27 TRP + CPD-479<=>INDOLE_PYRUVATE + MET
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
BioCyc:HUMAN_PWY-4361 S-methyl-5-thio-α-D-ribose 1-phosphate degradation
BioCyc:META_PWY-7527 L-methionine salvage cycle III
BioCyc:PCHR_PWY-5082 methionine degradation III
BioCyc:META_PWY-1186 L-homomethionine biosynthesis
BioCyc:META_PWY-7528 L-methionine salvage cycle I (bacteria and plants)
BioCyc:META_PWY-7270 L-methionine salvage cycle II (plants)
BioCyc:YEAST_PWY-5082 L-methionine degradation III
BioCyc:YEAST_PWY-6854 ethylene biosynthesis
BioCyc:HUMAN_PWY-7527 methionine salvage cycle III
BioCyc:META_PWY-6754 S-methyl-5'-thioadenosine degradation I
BioCyc:META_PWY-4361 S-methyl-5-thio-α-D-ribose 1-phosphate degradation I
BioCyc:META_PWY-6854 ethylene biosynthesis III (microbes)
BioCyc:LEISH_PWY3IU-1026 methionine salvage pathway
BioCyc:SYNEL_PWY-4361 S-methyl-5-thio-α-D-ribose 1-phosphate degradation
BioCyc:THAPS_PWY-5082 methionine degradation III
BioCyc:THAPS_PWY-6755 S-methyl-5-thio-α-D-ribose 1-phosphate degradation
BioCyc:META_PWY-6053 dimethylsulfoniopropanoate biosynthesis III (algae)
BioCyc:META_PWY-5082 L-methionine degradation III
BioCyc:YEAST_PWY3O-64 methionine salvage pathway
BioCyc:ARA_PWY-1186 L-homomethionine biosynthesis
View All Pathways