PI Metabolism
Gees M, Colsoul B, Nilius B. The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling. Cold Spring Harbor Perspectives in Biology. 2010 Sep 22;2(10):a003962. doi: 10.1101/cshperspect.a003962.; Liu Y, Bankaitis VA. Phosphoinositide phosphatases in cell biology and disease. Progress in Lipid Research. 2010 Jul;49(3):201–17. doi: 10.1016/j.plipres.2009.12.001.; Kutateladze TG. Translation of the phosphoinositide code by PI effectors. Nature Chemical Biology. 2010 Jun 17;6(7):507–13. doi: 10.1038/nchembio.390.; Leventis PA, Grinstein S. The distribution and function of phosphatidylserine in cellular membranes. Annu Rev Biophys. 2010;39():407–27. doi: 10.1146/annurev.biophys.093008.131234. PMID: 20192774.; McCrea HJ, De Camilli P. Mutations in phosphoinositide metabolizing enzymes and human disease. Physiology (Bethesda). 2009 Feb;24():8–16. PMID: 19196647; PMCID: PMC3499097.; Vicinanza M, D'Angelo G, Di Campli A, De Matteis MA. Function and dysfunction of the PI system in membrane trafficking. EMBO J. 2008 Oct 08;27(19):2457–70. PMID: 18784754; PMCID: PMC2536629.; Vicinanza M, D'Angelo G, Di Campli A, De Matteis MA. Phosphoinositides as regulators of membrane trafficking in health and disease. Cell Mol Life Sci. 2008 Sep;65(18):2833–41. PMID: 18726176; PMCID: PMC11131623.; Lemmon MA. Membrane recognition by phospholipid-binding domains. Nature Reviews Molecular Cell Biology. 2008 Feb;9(2):99–111. doi: 10.1038/nrm2328.; van Meer G, Voelker DR, Feigenson GW. Membrane lipids: where they are and how they behave. Nature Reviews Molecular Cell Biology. 2008 Feb;9(2):112–24. doi: 10.1038/nrm2330.; Blero D, Payrastre B, Schurmans S, Erneux C. Phosphoinositide phosphatases in a network of signalling reactions. Pflügers Archiv - European Journal of Physiology. 2007 Jun 29;455(1):31–44. doi: 10.1007/s00424-007-0304-5.; Krauss M, Haucke V. Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling. EMBO Rep. 2007 Mar;8(3):241–6. PMID: 17330069; PMCID: PMC1808040.; Di Paolo G, De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature. 2006 Oct 12;443(7112):651–7. doi: 10.1038/nature05185. PMID: 17035995.; Robinson FL, Dixon JE. Myotubularin phosphatases: policing 3-phosphoinositides. Trends Cell Biol. 2006 Aug;16(8):403–12. doi: 10.1016/j.tcb.2006.06.001. PMID: 16828287.; Roth MG. Phosphoinositides in constitutive membrane traffic. Physiol Rev. 2004 Jul;84(3):699–730. doi: 10.1152/physrev.00033.2003. PMID: 15269334.; De Matteis MA, Godi A. PI-loting membrane traffic. Nat Cell Biol. 2004 Jun;6(6):487–92. doi: 10.1038/ncb0604-487. PMID: 15170460.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.1.3.- | |||
| 2.7.1.137 | phosphatidylinositol 3-kinase | ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase | |
| 2.7.1.149 | 1-phosphatidylinositol-5-phosphate 4-kinase | ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase | |
| 2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase | ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase | |
| 2.7.1.67 | 1-phosphatidylinositol 4-kinase | ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase | |
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) | |
| 3.1.3.16 | protein-serine/threonine phosphatase | protein-serine/threonine-phosphate phosphohydrolase | |
| 3.1.3.48 | protein-tyrosine-phosphatase | protein-tyrosine-phosphate phosphohydrolase | |
| 3.1.3.64 | phosphatidylinositol-3-phosphatase | 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase | |
| 3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase | |
| 3.1.3.78 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase | 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | |
| 3.1.3.95 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase | 1-phosphatidyl-1D-myo-inositol-3,5-bisphosphate 3-phosphohydrolase | |
| 3.1.4.38 | glycerophosphocholine cholinephosphodiesterase | sn-glycero-3-phosphocholine cholinephosphohydrolase | |
| 3.1.4.44 | glycerophosphoinositol glycerophosphodiesterase | 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase | |
| 3.6.5.2 | small monomeric GTPase | GTP phosphohydrolase (cell-regulating) |
Proteins
| Protein ID | name | full name |
|---|