Cellular response to heat stress

Herbomel G, Kloster-Landsberg M, Folco EG, Col E, Usson Y, Vourc’h C, Delon A, Souchier C. Dynamics of the Full Length and Mutated Heat Shock Factor 1 in Human Cells. PLoS ONE. 2013 Jul 08;8(7):e67566. doi: 10.1371/journal.pone.0067566.; Kichine E, Rozé V, Di Cristofaro J, Taulier D, Navarro A, Streichemberger E, Decarpentrie F, Metzler-Guillemain C, Lévy N, Chiaroni J, Paquis-Flucklinger V, Fellmann F, Mitchell MJ. HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation. Hum Reprod. 2012 Feb;27(2):615–24. doi: 10.1093/humrep/der421. PMID: 22158087.; Kim SA, Yoon JH, Ahn SG. Heat shock factor 4a (HSF4a) represses HSF2 expression and HSF2-mediated transcriptional activity. J Cell Physiol. 2012 Jan;227(1):1–6. doi: 10.1002/jcp.22948. PMID: 21792930.; Anckar J, Sistonen L. Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease. Annu. Rev. Biochem. 2011 Jul 07;80(1):1089–115. doi: 10.1146/annurev-biochem-060809-095203.; Spriggs KA, Bushell M, Willis AE. Translational regulation of gene expression during conditions of cell stress. Mol Cell. 2010 Oct 22;40(2):228–37. doi: 10.1016/j.molcel.2010.09.028. PMID: 20965418.; Åkerfelt M, Morimoto RI, Sistonen L. Heat shock factors: integrators of cell stress, development and lifespan. Nature Reviews Molecular Cell Biology. 2010 Jul 14;11(8):545–55. doi: 10.1038/nrm2938.; Sandqvist A, Björk JK, Akerfelt M, Chitikova Z, Grichine A, Vourc'h C, Jolly C, Salminen TA, Nymalm Y, Sistonen L. Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. Mol Biol Cell. 2009 Mar;20(5):1340–7. PMID: 19129477; PMCID: PMC2649261.; Lu M, Kim HE, Li CR, Kim S, Kwak IJ, Lee YJ, Kim SS, Moon JY, Kim CH, Kim DK, Kang HS, Park JS. Two distinct disulfide bonds formed in human heat shock transcription factor 1 act in opposition to regulate its DNA binding activity. Biochemistry. 2008 Jun 03;47(22):6007–15. doi: 10.1021/bi702185u. PMID: 18457423.; Östling P, Björk JK, Roos-Mattjus P, Mezger V, Sistonen L. Heat Shock Factor 2 (HSF2) Contributes to Inducible Expression of hsp Genes through Interplay with HSF1. Journal of Biological Chemistry. 2007 Mar;282(10):7077–86. doi: 10.1074/jbc.m607556200.; Bhowmick BK, Takahata N, Watanabe M, Satta Y. Comparative analysis of human masculinity. Genet Mol Res. 2006 Nov 30;5(4):696–712. PMID: 17183480.; Shamovsky I, Ivannikov M, Kandel ES, Gershon D, Nudler E. RNA-mediated response to heat shock in mammalian cells. Nature. 2006 Mar 23;440(7083):556–60. doi: 10.1038/nature04518. PMID: 16554823.; Shinka T, Sato Y, Chen G, Naroda T, Kinoshita K, Unemi Y, Tsuji K, Toida K, Iwamoto T, Nakahori Y. Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. Biol Reprod. 2004 Jul;71(1):297–306. doi: 10.1095/biolreprod.103.023580. PMID: 15044259.; Sarkar A, Chattopadhyay S, Kaul R, Pal JK. Lead Exposure and Heat Shock Inhibit Cell Proliferation in Human HeLa and K562 Cells by Inducing Expression and Activity of the Heme-regulated eIF-2a Kinase. The Journal of Biochemistry, Molecular Biology and Biophysics. 2002 Dec 01;6(6):391–6. doi: 10.1080/1025814021000036124.; Yuan C, Gurley WB. Potential targets for HSF1 within the preinitiation complex. Cell Stress and Chaperones. 2000;5(3):229–42. doi: 10.1379/1466-1268(2000)005<0229:ptfhwt>2.0.co;2.; Tanabe M, Sasai N, Nagata K, Liu X, Liu PCC, Thiele DJ, Nakai A. The Mammalian HSF4Gene Generates Both an Activator and a Repressor of Heat Shock Genes by Alternative Splicing. Journal of Biological Chemistry. 1999 Sep;274(39):27845–56. doi: 10.1074/jbc.274.39.27845.; Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell. 1998 Aug 21;94(4):471–80. doi: 10.1016/s0092-8674(00)81588-3. PMID: 9727490.; Liu XD, Liu PC, Santoro N, Thiele DJ. Conservation of a stress response: human heat shock transcription factors functionally substitute for yeast HSF. EMBO J. 1997 Nov 03;16(21):6466–77. PMID: 9351828; PMCID: PMC1170252.; Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K. HSF4, a New Member of the Human Heat Shock Factor Family Which Lacks Properties of a Transcriptional Activator. Molecular and Cellular Biology. 1997 Jan 01;17(1):469–81. doi: 10.1128/mcb.17.1.469.; Zuo J, Rungger D, Voellmy R. Multiple Layers of Regulation of Human Heat Shock Transcription Factor 1. Molecular and Cellular Biology. 1995 Aug 01;15(8):4319–30. doi: 10.1128/mcb.15.8.4319.; Baler R, Dahl G, Voellmy R. Activation of Human Heat Shock Genes Is Accompanied by Oligomerization, Modification, and Rapid Translocation of Heat Shock Transcription Factor HSF1. Molecular and Cellular Biology. 1993 Apr 01;13(4):2486–96. doi: 10.1128/mcb.13.4.2486-2496.1993.; Sarge KD, Murphy SP, Morimoto RI. Activation of Heat Shock Gene Transcription by Heat Shock Factor 1 Involves Oligomerization, Acquisition of DNA-Binding Activity, and Nuclear Localization and Can Occur in the Absence of Stress. Molecular and Cellular Biology. 1993 Mar 01;13(3):1392–407. doi: 10.1128/mcb.13.3.1392-1407.1993.; Duncan RF, Hershey JW. Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation. J Cell Biol. 1989 Oct;109(4 Pt 1):1467–81. PMID: 2793930; PMCID: PMC2115803.

Metabolites

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.-
2.3.1.286 protein acetyllysine N-acetyltransferase [protein]-N6-acetyl-L-lysine:NAD+ N-acetyltransferase (NAD+-hydrolysing; 2''-O-acetyl-ADP-D-ribose-forming)
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase
3.6.4.10 non-chaperonin molecular chaperone ATPase ATP phosphohydrolase (polypeptide-polymerizing)
3.6.4.6 vesicle-fusing ATPase ATP phosphohydrolase (vesicle-fusing)
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase
5.3.99.3 prostaglandin-E synthase (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase


Proteins

Protein ID name full name