Cytosolic sensors of pathogen-associated DNA

Goubau D, Deddouche S, Reis e Sousa C. Cytosolic sensing of viruses. Immunity. 2013 May 23;38(5):855–69. PMID: 23706667; PMCID: PMC7111113.; Paludan SR, Bowie AG. Immune sensing of DNA. Immunity. 2013 May 23;38(5):870–80. PMID: 23706668; PMCID: PMC3683625.; Sharma S, Fitzgerald KA. Innate Immune Sensing of DNA. PLoS Pathog. 2011 Apr 21;7(4):e1001310. doi: 10.1371/journal.ppat.1001310.

Metabolites

3',5'-Cyclic diGMP

Formula: C20H24N10O14P2 (690.0948664)

CAS ID: 61093-23-0

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.1.-.-
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.10 IkappaB kinase ATP:[IkappaB protein] phosphotransferase
3.6.4.13 RNA helicase


Proteins

Protein ID name full name