Platelet sensitization by LDL

Korporaal SJA, Relou IAM, van Eck M, Strasser V, Bezemer M, Gorter G, van Berkel TJC, Nimpf J, Akkerman JN, Lenting PJ. Binding of Low Density Lipoprotein to Platelet Apolipoprotein E Receptor 2' Results in Phosphorylation of p38MAPK. Journal of Biological Chemistry. 2004 Dec;279(50):52526–34. doi: 10.1074/jbc.m407407200.; Relou IAM, Gorter G, Ferreira IA, van Rijn HJM, Akkerman JN. Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Inhibits Low Density Lipoprotein-induced Signaling in Platelets. Journal of Biological Chemistry. 2003 Aug;278(35):32638–44. doi: 10.1074/jbc.m212675200.; Gorter G, van Rijn JMH, Akkerman NJ-, Relou IAM. Platelet Activation by the apoB/E Receptor-binding Domain of LDL. Thromb Haemost. 2002;87(05):880–7. doi: 10.1055/s-0037-1613100.

Metabolites

Cholesterol

Formula: C27H46O (386.3548466)

CAS ID: 57-88-5

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.1.1.5 lysophospholipase 2-lysophosphatidylcholine acylhydrolase
3.1.3.48 protein-tyrosine-phosphatase protein-tyrosine-phosphate phosphohydrolase


Proteins

Protein ID name full name