Epigenetic regulation of gene expression

Almeida MV, Vernaz G, Putman ALK, Miska EA. Taming transposable elements in vertebrates: from epigenetic silencing to domestication. Trends Genet. 2022 Jun;38(6):529–53. doi: 10.1016/j.tig.2022.02.009. PMID: 35307201.; Guarnaccia AD, Tansey WP. Moonlighting with WDR5: A Cellular Multitasker. J Clin Med. 2018 Jan 30;7(2). PMID: 29385767; PMCID: PMC5852437.; Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003 Mar;33 Suppl():245–54. doi: 10.1038/ng1089. PMID: 12610534.

Metabolites

Nicotinamide

Formula: C6H6N2O (122.0480106)

CAS ID: 98-92-0

Cytosine-5-carboxylic acid

Formula: C5H5N3O3 (155.03309000000002)

CAS ID: 3650-93-9

5-Formylcytosine

Formula: C5H5N3O2 (139.03817500000002)

CAS ID: 4425-59-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

2''-O-acetyl-ADP-D-ribose(2-)

Formula: C17H23N5O15P2 (599.0665868000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.1.-
2.1.1.356 [histone H3]-lysine27 N-trimethyltransferase S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-methyltransferase
2.1.1.366 [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase S-adenosyl-L-methionine:[histone H3]-N6,N6-dimethyl-L-lysine9 N6-methyltransferase
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.3.1.57 diamine N-acetyltransferase acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase


Proteins

Protein ID name full name