Stimuli-sensing channels

Qadri YJ, Rooj AK, Fuller CM. ENaCs and ASICs as therapeutic targets. American Journal of Physiology-Cell Physiology. 2012 Apr 01;302(7):C943–65. doi: 10.1152/ajpcell.00019.2012.; Takahashi N, Kozai D, Mori Y. TRP channels: sensors and transducers of gasotransmitter signals. Front Physiol. 2012;3():324. PMID: 22934072; PMCID: PMC3429092.; Wang YZ, Xu TL. Acidosis, acid-sensing ion channels, and neuronal cell death. Mol Neurobiol. 2011 Dec;44(3):350–8. doi: 10.1007/s12035-011-8204-2. PMID: 21932071.; Deval E, Gasull X, Noël J, Salinas M, Baron A, Diochot S, Lingueglia E. Acid-sensing ion channels (ASICs): pharmacology and implication in pain. Pharmacol Ther. 2010 Dec;128(3):549–58. doi: 10.1016/j.pharmthera.2010.08.006. PMID: 20807551.; Kunzelmann K, Kongsuphol P, Aldehni F, Tian Y, Ousingsawat J, Warth R, Schreiber R. Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions. Cell Calcium. 2009 Oct;46(4):233–41. doi: 10.1016/j.ceca.2009.09.003. PMID: 19783045.; Beard NA, Wei L, Dulhunty AF. Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen. Clin Exp Pharmacol Physiol. 2009 Mar;36(3):340–5. doi: 10.1111/j.1440-1681.2008.05094.x. PMID: 19278523.; Hartzell HC, Qu Z, Yu K, Xiao Q, Chien LT. Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies. Physiol Rev. 2008 Apr;88(2):639–72. doi: 10.1152/physrev.00022.2007. PMID: 18391176.; Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu Rev Physiol. 2006;68():619–47. doi: 10.1146/annurev.physiol.68.040204.100431. PMID: 16460286.; Suzuki M. The Drosophilatweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels. Experimental Physiology. 2005 Dec 20;91(1):141–7. doi: 10.1113/expphysiol.2005.031773.; Montell C. The TRP superfamily of cation channels. Sci STKE. 2005 Feb 22;2005(272):re3. doi: 10.1126/stke.2722005re3. PMID: 15728426.; Tsunenari T, Sun H, Williams J, Cahill H, Smallwood P, Yau K, Nathans J. Structure-Function Analysis of the Bestrophin Family of Anion Channels. Journal of Biological Chemistry. 2003 Oct;278(42):41114–25. doi: 10.1074/jbc.m306150200.; Sun H, Tsunenari T, Yau KW, Nathans J. The vitelliform macular dystrophy protein defines a new family of chloride channels. Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):4008–13. PMID: 11904445; PMCID: PMC122639.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Cl-

Formula: Cl (34.968853)

CAS ID: 16887-00-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

Urate

Formula: C5H4N4O3 (168.0283394)

CAS ID: 69-93-2

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
1.14.11.16 peptide-aspartate beta-dioxygenase peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase


Proteins

Protein ID name full name