Glutathione synthesis and recycling

Meister A. Glutathione metabolism and its selective modification. Journal of Biological Chemistry. 1988 Nov;263(33):17205–8. doi: 10.1016/s0021-9258(19)77815-6.

Metabolites

Glutathione

Formula: C10H17N3O6S (307.08380220000004)

CAS ID: 70-18-8

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

5-oxo-L-prolinate

Formula: C5H6NO3 (128.0347666)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
3.4.13.-
2.3.2.2 gamma-glutamyltransferase (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase
3.4.19.13 glutathione gamma-glutamate hydrolase
3.5.2.9 5-oxoprolinase (ATP-hydrolysing) 5-oxo-L-proline amidohydrolase (ATP-hydrolysing)
4.3.2.7 glutathione-specific gamma-glutamylcyclotransferase glutathione gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)
6.3.2.3 glutathione synthase gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)


Proteins

Protein ID name full name
P28273 OXP1 5-oxoprolinase
P32656 GCG1 Glutathione-specific gamma-glutamylcyclotransferase
P43616 DUG1 Cys-Gly metallodipeptidase DUG1
Q05902 ECM38 Glutathione hydrolase proenzyme
Q08220 GSH2 Glutathione synthetase GSH2