EC: 4.3.2.7

glutathione-specific gamma-glutamylcyclotransferase (glutathione gamma-glutamyl cyclotransferase (5-oxo-L-proline producing))

enzyme lambda metabolic reaction experiment
uniprot:Q8R3J5 [glutathione-specific gamma-glutamylcyclotransferase(Enzyme) wildtype Chac1 His-tagged]

Reduced_glutathione -> L_Cysteinylglycine + 5_Oxoproline		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl
PH: 8
Temperature: 37
uniprot:P32656 [glutathione-specific gamma-glutamylcyclotransferase(Enzyme) wildtype YER163c His-tagged]

Reduced_glutathione -> L_Cysteinylglycine + 5_Oxoproline		 (( (Vmax * S) ) / (Km + S)) buffer: 50 mM Tris-HCl
PH: 8
Temperature: 37
uniprot:Q84MC1 [glutathione-specific gamma-glutamylcyclotransferase(Enzyme) wildtype GGCT2;2 His-tagged]

Reduced_glutathione -> 5_Oxoproline + L_Cysteinylglycine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Tris-HCl
PH: 8
Temperature: 37
uniprot:Q84QC1 [glutathione-specific gamma-glutamylcyclotransferase(Enzyme) wildtype GGCT2;3 His-tagged]

Reduced_glutathione -> L_Cysteinylglycine + 5_Oxoproline		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Tris-HCl
PH: 8
Temperature: 37

Pathways

pathway id name
Reactome:R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-174403 Glutathione synthesis and recycling
Reactome:R-SCE-156580 Phase II - Conjugation of compounds
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-SCE-211859 Biological oxidations
Reactome:R-SCE-156590 Glutathione conjugation