Biotin transport and metabolism

Zempleni J, Wijeratne SS, Hassan YI. Biotin. Biofactors. 2009 Jan;35(1):36–46. PMID: 19319844; PMCID: PMC4757853.

Metabolites

Biotin

Formula: C10H16N2O3S (244.08815859999999)

CAS ID: 58-85-5

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:



Enzyme

EC Number name full name note
6.3.4.-
6.3.4.10 biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase biotin:apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)
6.3.4.11 biotin-[methylcrotonoyl-CoA-carboxylase] ligase biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)
6.3.4.14 biotin carboxylase [biotin carboxyl-carrier protein]-biotin-N6-L-lysine:hydrogencarbonate ligase (ADP-forming)
6.3.4.15 biotin-[biotin carboxyl-carrier protein] ligase biotin:apo-[carboxyl-carrier protein] ligase (AMP-forming)
6.3.4.9 biotin-[methylmalonyl-CoA-carboxytransferase] ligase biotin:apo[methylmalonyl-CoA:pyruvate carboxytransferase] ligase (AMP-forming)
6.4.1.1 pyruvate carboxylase pyruvate:carbon-dioxide ligase (ADP-forming)
6.4.1.2 acetyl-CoA carboxylase acetyl-CoA:hydrogencarbonate ligase (ADP-forming)


Proteins

Protein ID name full name
P11154 PYC1 Pyruvate carboxylase 1
P48445 BPL1 Biotin--protein ligase
Q00955 ACC1 Acetyl-CoA carboxylase