Glycerophospholipid biosynthesis
Orsó E, Grandl M, Schmitz G. Oxidized LDL-induced endolysosomal phospholipidosis and enzymatically modified LDL-induced foam cell formation determine specific lipid species modulation in human macrophages. Chem Phys Lipids. 2011 Sep;164(6):479–87. doi: 10.1016/j.chemphyslip.2011.06.001. PMID: 21683693.; Scherer M, Schmitz G. Metabolism, function and mass spectrometric analysis of bis(monoacylglycero)phosphate and cardiolipin. Chem Phys Lipids. 2011 Sep;164(6):556–62. doi: 10.1016/j.chemphyslip.2011.06.007. PMID: 21704024.; Hermansson M, Hokynar K, Somerharju P. Mechanisms of glycerophospholipid homeostasis in mammalian cells. Prog Lipid Res. 2011 Jul;50(3):240–57. doi: 10.1016/j.plipres.2011.02.004. PMID: 21382416.; Osman C, Voelker DR, Langer T. Making heads or tails of phospholipids in mitochondria. J Cell Biol. 2011 Jan 10;192(1):7–16. PMID: 21220505; PMCID: PMC3019561.; Lev S. Non-vesicular lipid transport by lipid-transfer proteins and beyond. Nature Reviews Molecular Cell Biology. 2010 Sep 08;11(10):739–50. doi: 10.1038/nrm2971.; Lebiedzinska M, Szabadkai G, Jones AWE, Duszynski J, Wieckowski MR. Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles. The International Journal of Biochemistry & Cell Biology. 2009 Oct;41(10):1805–16. doi: 10.1016/j.biocel.2009.02.017.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.3.-.- | |||
| 1.1.5.3 | glycerol-3-phosphate dehydrogenase | sn-glycerol 3-phosphate:quinone oxidoreductase | |
| 2.1.1.17 | phosphatidylethanolamine N-methyltransferase | S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase | |
| 2.1.1.71 | phosphatidyl-N-methylethanolamine N-methyltransferase | S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase | |
| 2.3.1.20 | diacylglycerol O-acyltransferase | acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase | |
| 2.3.1.22 | 2-acylglycerol O-acyltransferase | acyl-CoA:2-acylglycerol O-acyltransferase | |
| 2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase | acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase | |
| 2.3.1.51 | 1-acylglycerol-3-phosphate O-acyltransferase | acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase | |
| 2.3.1.7 | carnitine O-acetyltransferase | acetyl-CoA:carnitine O-acetyltransferase | |
| 2.7.1.32 | choline kinase | ATP:choline phosphotransferase | |
| 2.7.1.91 | sphingosine kinase | ATP:sphingoid base 1-phosphotransferase | |
| 2.7.7.14 | ethanolamine-phosphate cytidylyltransferase | CTP:ethanolamine-phosphate cytidylyltransferase | |
| 2.7.7.15 | choline-phosphate cytidylyltransferase | CTP:choline-phosphate cytidylyltransferase | |
| 2.7.7.41 | phosphatidate cytidylyltransferase | CTP:phosphatidate cytidylyltransferase | |
| 2.7.8.11 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase | CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase | |
| 2.7.8.2 | diacylglycerol cholinephosphotransferase | CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase | |
| 2.7.8.41 | cardiolipin synthase (CMP-forming) | CDP-diacylglycerol:L-1-phosphatidyl-glycerol diacylglycerolphosphotransferase (CMP-forming) | |
| 3.1.1.23 | acylglycerol lipase | glycerol-ester acylhydrolase | |
| 3.1.3.1 | alkaline phosphatase | phosphate-monoester phosphohydrolase (alkaline optimum) | |
| 3.1.3.4 | phosphatidate phosphatase | diacylglycerol-3-phosphate phosphohydrolase | |
| 3.1.3.54 | fructose-2,6-bisphosphate 6-phosphatase | beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase | |
| 3.1.4.4 | phospholipase D | phosphatidylcholine phosphatidohydrolase | |
| 3.1.7.6 | farnesyl diphosphatase | (2E,6E)-farnesyl-diphosphate diphosphohydrolase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P05375 | OPI3 | Phosphatidyl-N-methylethanolamine N-methyltransferase |
| P06197 | PIS1 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
| P11491 | PHO8 | Repressible alkaline phosphatase |
| P13259 | PCT1 | Choline-phosphate cytidylyltransferase |
| P17898 | CPT1 | Cholinephosphotransferase 1 |
| P20485 | CKI1 | Choline kinase |
| P28321 | YJU3 | Monoglyceride lipase |
| P32191 | GUT2 | Glycerol-3-phosphate dehydrogenase, mitochondrial |
| P32567 | PAH1 | Phosphatidic acid phosphohydrolase 1 |
| P32796 | CAT2 | Carnitine O-acetyltransferase, mitochondrial |
| P33412 | ECT1 | Ethanolamine-phosphate cytidylyltransferase |
| P36126 | SPO14 | Phospholipase D1 |
| P38221 | CDS1 | Phosphatidate cytidylyltransferase |
| P38226 | CST26 | 2-acyl-1-lysophosphatidylinositol acyltransferase |
| P53264 | CLD1 | Cardiolipin-specific deacylase 1, mitochondrial |
| Q06147 | LCB5 | Sphingoid long chain base kinase 5 |
| Q06510 | TAZ1 | Tafazzin |
| Q07560 | CRD1 | Cardiolipin synthase (CMP-forming) |
| Q08548 | ALE1 | Lysophospholipid acyltransferase |
| Q08650 | DGA1 | Diacylglycerol O-acyltransferase 1 |
| Q12204 | YOR22_YEAST | Probable phospholipase YOR022C, mitochondrial |