HSF1-dependent transactivation

Guettouche T, Boellmann F, Lane WS, Voellmy R. Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Molecular and Cell Biology. 2005 Mar 11;6(1):4. doi: 10.1186/1471-2091-6-4.; Trinklein ND, Murray JI, Hartman SJ, Botstein D, Myers RM. The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response. Mol Biol Cell. 2004 Mar;15(3):1254–61. PMID: 14668476; PMCID: PMC363119.; Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J. 2001 Jul 16;20(14):3800–10. PMID: 11447121; PMCID: PMC125548.; Brown SA, Weirich CS, Newton EM, Kingston RE. Transcriptional activation domains stimulate initiation and elongation at different times and via different residues. EMBO J. 1998 Jun 01;17(11):3146–54. PMID: 9606196; PMCID: PMC1170653.; Kline MP, Morimoto RI. Repression of the Heat Shock Factor 1 Transcriptional Activation Domain Is Modulated by Constitutive Phosphorylation. Molecular and Cellular Biology. 1997 Apr 01;17(4):2107–15. doi: 10.1128/mcb.17.4.2107.; Ding XZ, Tsokos GC, Kiang JG. Heat shock factor-1 protein in heat shock factor-1 gene-transfected human epidermoid A431 cells requires phosphorylation before inducing heat shock protein-70 production. J Clin Invest. 1997 Jan 01;99(1):136–43. PMID: 9011567; PMCID: PMC507777.; Newton EM, Knauf U, Green M, Kingston RE. The Regulatory Domain of Human Heat Shock Factor 1 Is Sufficient To Sense Heat Stress. Molecular and Cellular Biology. 1996 Mar 01;16(3):839–46. doi: 10.1128/mcb.16.3.839.; Cotto JJ, Kline M, Morimoto RI. Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation. J Biol Chem. 1996 Feb 16;271(7):3355–8. doi: 10.1074/jbc.271.7.3355. PMID: 8631933.; Zuo J, Rungger D, Voellmy R. Multiple Layers of Regulation of Human Heat Shock Transcription Factor 1. Molecular and Cellular Biology. 1995 Aug 01;15(8):4319–30. doi: 10.1128/mcb.15.8.4319.; Green M, Schuetz TJ, Sullivan EK, Kingston RE. A Heat Shock-Responsive Domain of Human HSF1 That Regulates Transcription Activation Domain Function. Molecular and Cellular Biology. 1995 Jun 01;15(6):3354–62. doi: 10.1128/mcb.15.6.3354.

Metabolites

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
5.2.1.8 peptidylprolyl isomerase Peptidylproline cis-trans-isomerase
5.3.99.3 prostaglandin-E synthase (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase


Proteins

Protein ID name full name