alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Burdge GC. Metabolism of alpha-linolenic acid in humans. Prostaglandins Leukot Essent Fatty Acids. 2006 Sep;75(3):161–8. doi: 10.1016/j.plefa.2006.05.013. PMID: 16828546.; Sprecher H. The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2002 Aug;67(2-3):79–83. doi: 10.1054/plef.2002.0402. PMID: 12324224.; Sprecher H. Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2000 Jul;1486(2-3):219–31. doi: 10.1016/s1388-1981(00)00077-9.
Metabolites
(3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA
Formula: C45H70N7O18P3S (1121.371071)
CAS ID:
(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA
Formula: C45H68N7O17P3S (1103.3605068000002)
CAS ID:
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.3.3.- | |||
| 1.14.19.37 | acyl-CoA 5-desaturase | acyl-CoA,acceptor:oxygen oxidoreductase (5,6 cis-dehydrogenating) | |
| 1.14.19.44 | acyl-CoA (8-3)-desaturase | DELTA8-acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (5,6-cis-dehydrogenating) | |
| 2.3.1.199 | very-long-chain 3-oxoacyl-CoA synthase | malonyl-CoA:very-long-chain acyl-CoA malonyltransferase (decarboxylating and thioester-hydrolysing) |
Proteins
| Protein ID | name | full name |
|---|