Synthesis of IP3 and IP4 in the cytosol

Bunney TD, Katan M. Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer. 2010 May;10(5):342–52. doi: 10.1038/nrc2842. PMID: 20414202.; Irvine RF, Schell MJ. Back in the water: the return of the inositol phosphates. Nature Reviews Molecular Cell Biology. 2001 May;2(5):327–38. doi: 10.1038/35073015.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

D-myo-inositol (1,3,4)-trisphosphate

Formula: C6H9O15P3 (413.91543540000004)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)

Formula: C6H8O18P4 (491.86611880000004)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.134 inositol-tetrakisphosphate 1-kinase ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase
2.7.1.159 inositol-1,3,4-trisphosphate 5/6-kinase ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase
3.1.4.11 phosphoinositide phospholipase C 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase


Proteins

Protein ID name full name