Catecholamine biosynthesis

Flatmark T. Catecholamine biosynthesis and physiological regulation in neuroendocrine cells. Acta Physiol Scand. 2000 Jan;168(1):1–17. doi: 10.1046/j.1365-201x.2000.00596.x. PMID: 10691773.; Nagatsu T. Genes for human catecholamine-synthesizing enzymes. Neurosci Res. 1991 Oct;12(2):315–45. doi: 10.1016/0168-0102(91)90001-f. PMID: 1684650.; Laverty R. Catecholamines: role in health and disease. Drugs. 1978 Nov;16(5):418–40. doi: 10.2165/00003495-197816050-00003. PMID: 363400.

Metabolites

4a-Hydroxytetrahydrobiopterin

Formula: C9H15N5O4 (257.11239900000004)

CAS ID: 1379003-93-6

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

PQQ

Formula: C14H6N2O8 (330.0124156)

CAS ID: 72909-34-3

dopaminium(1+)

Formula: C8H12NO2 (154.0867992)

CAS ID:



Enzyme

EC Number name full name note
1.14.16.2 tyrosine 3-monooxygenase L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
1.14.17.1 dopamine beta-monooxygenase dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
2.1.1.28 phenylethanolamine N-methyltransferase S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
4.1.1.28 aromatic-L-amino-acid decarboxylase Aromatic-L-amino-acid carboxy-lyase


Proteins

Protein ID name full name