D-galactose degradation I (Leloir pathway)

Frey PA. The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. The FASEB Journal. 1996 Mar;10(4):461–70. doi: 10.1096/fasebj.10.4.8647345.

Metabolites

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

alpha-D-Galactose

Formula: C6H12O6 (180.0633852)

CAS ID: 3646-73-9

beta-D-Galactose

Formula: C6H12O6 (180.0633852)

CAS ID: 7296-64-2

D-Glucose 6-phosphate

Formula: C6H13O9P (260.0297178)

CAS ID: 56-73-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Sodium chloride

Formula: NaCl (57.958623)

CAS ID: 7647-14-5

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP-alpha-D-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0



Enzyme

EC Number name full name note
2.7.1.6 galactokinase ATP:D-galactose 1-phosphotransferase
5.1.3.2 UDP-glucose 4-epimerase UDP-glucose 4-epimerase
5.1.3.5 UDP-arabinose 4-epimerase UDP-L-arabinose 4-epimerase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) alpha-D-glucose 1,6-phosphomutase


Proteins

Protein ID name full name