Opioid Signalling

Martin-Kleiner I, Balog T, Gabrilovac J. Signal transduction induced by opioids in immune cells: a review. Neuroimmunomodulation. 2006;13(1):1–7. doi: 10.1159/000092107. PMID: 16612131.; Hamm HE. The Many Faces of G Protein Signaling. Journal of Biological Chemistry. 1998 Jan;273(2):669–72. doi: 10.1074/jbc.273.2.669.; Standifer KM, Pasternak GW. G proteins and opioid receptor-mediated signalling. Cell Signal. 1997 May;9(3-4):237–48. doi: 10.1016/s0898-6568(96)00174-x. PMID: 9218123.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic AMP(1-)

Formula: C10H11N5O6P (328.0446936)

CAS ID: 62906-31-4



Enzyme

EC Number name full name note
3.6.5.-
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.11 cAMP-dependent protein kinase ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent)
2.7.11.15 beta-adrenergic-receptor kinase ATP:[beta-adrenergic receptor] phosphotransferase
2.7.11.17 Ca2+/calmodulin-dependent protein kinase ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.1.1.5 lysophospholipase 2-lysophosphatidylcholine acylhydrolase
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase


Proteins

Protein ID name full name