Epigenetic regulation of gene expression

Almeida MV, Vernaz G, Putman ALK, Miska EA. Taming transposable elements in vertebrates: from epigenetic silencing to domestication. Trends Genet. 2022 Jun;38(6):529–53. doi: 10.1016/j.tig.2022.02.009. PMID: 35307201.; Guarnaccia AD, Tansey WP. Moonlighting with WDR5: A Cellular Multitasker. J Clin Med. 2018 Jan 30;7(2). PMID: 29385767; PMCID: PMC5852437.; Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003 Mar;33 Suppl():245–54. doi: 10.1038/ng1089. PMID: 12610534.

Metabolites

Cytosine-5-carboxylic acid

Formula: C5H5N3O3 (155.03309000000002)

CAS ID: 3650-93-9

5-Formylcytosine

Formula: C5H5N3O2 (139.03817500000002)

CAS ID: 4425-59-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.1.1.-
1.14.11.68 [histone H3]-trimethyl-L-lysine27 demethylase [histone H3]-N6,N6,N6-trimethyl-L-lysine27,2-oxoglutarate:oxygen oxidoreductase
2.1.1.356 [histone H3]-lysine27 N-trimethyltransferase S-adenosyl-L-methionine:[histone H3]-L-lysine27 N6-methyltransferase
2.1.1.364 [histone H3]-lysine4 N-methyltransferase S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-methyltransferase
2.1.1.366 [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase S-adenosyl-L-methionine:[histone H3]-N6,N6-dimethyl-L-lysine9 N6-methyltransferase
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase
2.3.1.57 diamine N-acetyltransferase acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase
2.3.2.27 RING-type E3 ubiquitin transferase [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type)
2.4.1.255 protein O-GlcNAc transferase UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.26 tau-protein kinase ATP:[tau-protein] O-phosphotransferase
2.7.7.6 DNA-directed RNA polymerase nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
3.2.2.29 thymine-DNA glycosylase thymine-DNA deoxyribohydrolase (thymine-releasing)
3.6.4.13 RNA helicase


Proteins

Protein ID name full name