Complement cascade
Benoit ME, Clarke EV, Morgado P, Fraser DA, Tenner AJ. Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J Immunol. 2012 Jun 01;188(11):5682–93. PMID: 22523386; PMCID: PMC3358549.; Braunschweig A, Józsi M. Human Pentraxin 3 Binds to the Complement Regulator C4b-Binding Protein. PLoS ONE. 2011 Aug 22;6(8):e23991. doi: 10.1371/journal.pone.0023991.; Oikonomopoulou K, Ricklin D, Ward PA, Lambris JD. Interactions between coagulation and complement—their role in inflammation. Seminars in Immunopathology. 2011 Aug 03;34(1):151–65. doi: 10.1007/s00281-011-0280-x.; Morgan HP, Schmidt CQ, Guariento M, Blaum BS, Gillespie D, Herbert AP, Kavanagh D, Mertens HDT, Svergun DI, Johansson CM, Uhrín D, Barlow PN, Hannan JP. Structural basis for engagement by complement factor H of C3b on a self surface. Nature Structural & Molecular Biology. 2011 Feb 13;18(4):463–70. doi: 10.1038/nsmb.2018.; Forneris F, Ricklin D, Wu J, Tzekou A, Wallace RS, Lambris JD, Gros P. Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science. 2010 Dec 24;330(6012):1816–20. PMID: 21205667; PMCID: PMC3087196.; Amara U, Flierl MA, Rittirsch D, Klos A, Chen H, Acker B, Brückner UB, Nilsson B, Gebhard F, Lambris JD, Huber-Lang M. Molecular intercommunication between the complement and coagulation systems. J Immunol. 2010 Nov 01;185(9):5628–36. PMID: 20870944; PMCID: PMC3123139.; Garcia BL, Ramyar KX, Tzekou A, Ricklin D, McWhorter WJ, Lambris JD, Geisbrecht BV. Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b. Journal of Molecular Biology. 2010 Sep;402(1):17–29. doi: 10.1016/j.jmb.2010.07.029.; Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010 Sep;11(9):785–97. PMID: 20720586; PMCID: PMC2924908.; Serruto D, Rappuoli R, Scarselli M, Gros P, van Strijp JA. Molecular mechanisms of complement evasion: learning from staphylococci and meningococci. Nat Rev Microbiol. 2010 Jun;8(6):393–9. doi: 10.1038/nrmicro2366. PMID: 20467445.; Hajishengallis G, Lambris JD. Crosstalk pathways between Toll-like receptors and the complement system. Trends in Immunology. 2010 Apr;31(4):154–63. doi: 10.1016/j.it.2010.01.002.; Nilsson SC, Nita I, Månsson L, Groeneveld TWL, Trouw LA, Villoutreix BO, Blom AM. Analysis of Binding Sites on Complement Factor I That Are Required for Its Activity. Journal of Biological Chemistry. 2010 Feb;285(9):6235–45. doi: 10.1074/jbc.m109.097212.; Fraser DA, Laust AK, Nelson EL, Tenner AJ. C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells. J Immunol. 2009 Nov 15;183(10):6175–85. PMID: 19864605; PMCID: PMC2843563.; Gullstrand B, Mårtensson U, Sturfelt G, Bengtsson AA, Truedsson L. Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells. Clin Exp Immunol. 2009 May;156(2):303–11. PMID: 19302245; PMCID: PMC2759479.; Kang YH, Tan LA, Carroll MV, Gentle ME, Sim RB. Target pattern recognition by complement proteins of the classical and alternative pathways. Adv Exp Med Biol. 2009;653():117–28. doi: 10.1007/978-1-4419-0901-5_8. PMID: 19799115.; Kemper C, Mitchell LM, Zhang L, Hourcade DE. The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis. Proc Natl Acad Sci U S A. 2008 Jul 01;105(26):9023–8. PMID: 18579773; PMCID: PMC2449358.; Lambris JD, Ricklin D, Geisbrecht BV. Complement evasion by human pathogens. Nature Reviews Microbiology. 2008 Feb;6(2):132–42. doi: 10.1038/nrmicro1824.; Trouw LA, Bengtsson AA, Gelderman KA, Dahlbäck B, Sturfelt G, Blom AM. C4b-binding Protein and Factor H Compensate for the Loss of Membrane-bound Complement Inhibitors to Protect Apoptotic Cells against Excessive Complement Attack. Journal of Biological Chemistry. 2007 Sep;282(39):28540–8. doi: 10.1074/jbc.m704354200.; Pedersen ED, Aass HC, Rootwelt T, Fung M, Lambris JD, Mollnes TE. CD59 efficiently protects human NT2-N neurons against complement-mediated damage. Scand J Immunol. 2007 Aug;66(2-3):345–51. doi: 10.1111/j.1365-3083.2007.01959.x. PMID: 17635812.; van Bruggen R, Zweers D, van Diepen A, van Dissel JT, Roos D, Verhoeven AJ, Kuijpers TW. Complement receptor 3 and Toll-like receptor 4 act sequentially in uptake and intracellular killing of unopsonized Salmonella enterica serovar Typhimurium by human neutrophils. Infect Immun. 2007 Jun;75(6):2655–60. PMID: 17353285; PMCID: PMC1932891.; Kagan JC, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 2006 Jun 02;125(5):943–55. doi: 10.1016/j.cell.2006.03.047. PMID: 16751103.; Köhl J. The role of complement in danger sensing and transmission. Immunol Res. 2006;34(2):157–76. doi: 10.1385/ir:34:2:157. PMID: 16760575.; Reca R, Wysoczynski M, Yan J, Lambris JD, Ratajczak MZ. The role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow. Adv Exp Med Biol. 2006;586():35–51. doi: 10.1007/0-387-34134-x_3. PMID: 16893063.; Elward K, Griffiths M, Mizuno M, Harris CL, Neal JW, Morgan BP, Gasque P. CD46 Plays a Key Role in Tailoring Innate Immune Recognition of Apoptotic and Necrotic Cells. Journal of Biological Chemistry. 2005 Oct;280(43):36342–54. doi: 10.1074/jbc.m506579200.; Gasque P. Complement: a unique innate immune sensor for danger signals. Mol Immunol. 2004 Nov;41(11):1089–98. doi: 10.1016/j.molimm.2004.06.011. PMID: 15476920.; Bernet J, Mullick J, Panse Y, Parab PB, Sahu A. Kinetic Analysis of the Interactions between Vaccinia Virus Complement Control Protein and Human Complement Proteins C3b and C4b. J Virol. 2004 Sep;78(17):9446–57. doi: 10.1128/jvi.78.17.9446-9457.2004.; Nonaka M, Yoshizaki F. Evolution of the complement system. Mol Immunol. 2004 Feb;40(12):897–902. doi: 10.1016/j.molimm.2003.10.009. PMID: 14698228.; Iborra A, Mayorga M, Llobet N, Martínez P. Expression of complement regulatory proteins [membrane cofactor protein (CD46), decay accelerating factor (CD55), and protectin (CD59)] in endometrial stressed cells. Cell Immunol. 2003 May;223(1):46–51. doi: 10.1016/s0008-8749(03)00127-8. PMID: 12914757.; Barilla-LaBarca ML, Liszewski MK, Lambris JD, Hourcade D, Atkinson JP. Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol. 2002 Jun 15;168(12):6298–304. doi: 10.4049/jimmunol.168.12.6298. PMID: 12055245.; Smith BO, Mallin RL, Krych-Goldberg M, Wang X, Hauhart RE, Bromek K, Uhrin D, Atkinson JP, Barlow PN. Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor. Cell. 2002 Mar 22;108(6):769–80. doi: 10.1016/s0092-8674(02)00672-4. PMID: 11955431.; Hensel F, Hermann R, Brändlein S, Krenn V, Schmausser B, Geis S, Müller-Hermelink HK, Vollmers HP. Regulation of the New Coexpressed CD55 (Decay-Accelerating Factor) Receptor on Stomach Carcinoma Cells Involved in Antibody SC-1–Induced Apoptosis. Laboratory Investigation. 2001 Nov 01;81(11):1553–63. doi: 10.1038/labinvest.3780369.; Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, Henson PM. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med. 2001 Sep 17;194(6):781–95. PMID: 11560994; PMCID: PMC2195958.; Navratil JS, Watkins SC, Wisnieski JJ, Ahearn JM. The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cells. J Immunol. 2001 Mar 01;166(5):3231–9. doi: 10.4049/jimmunol.166.5.3231. PMID: 11207277.; Mold C, Morris CA. Complement activation by apoptotic endothelial cells following hypoxia/reoxygenation. Immunology. 2001 Mar;102(3):359–64. doi: 10.1046/j.1365-2567.2001.01192.x.; Schmidt BZ, Colten HR. Complement: a critical test of its biological importance. Immunol Rev. 2000 Dec;178():166–76. doi: 10.1034/j.1600-065x.2000.17801.x. PMID: 11213801.; Gershov D, Kim S, Brot N, Elkon KB. C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. J Exp Med. 2000 Nov 06;192(9):1353–64. PMID: 11067883; PMCID: PMC2193350.; Sim RB, Laich A. Serine proteases of the complement system. Biochem Soc Trans. 2000 Oct;28(5):545–50. doi: 10.1042/bst0280545. PMID: 11044372.; Mevorach D, Mascarenhas JO, Gershov D, Elkon KB. Complement-dependent clearance of apoptotic cells by human macrophages. J Exp Med. 1998 Dec 21;188(12):2313–20. PMID: 9858517; PMCID: PMC2212421.; Mongini PK, Vilensky MA, Highet PF, Inman JK. The affinity threshold for human B cell activation via the antigen receptor complex is reduced upon co-ligation of the antigen receptor with CD21 (CR2). 1997 Oct 15;159(8):3782–91. doi: 10.4049/jimmunol.159.8.3782.; Korb LC, Ahearn JM. C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. 1997 May 15;158(10):4525–8. doi: 10.4049/jimmunol.158.10.4525.; NIELSEN CH, MATTHIESEN SH, LYNG I, LESLIE RGQ. The role of complement receptor type 1 (CR1, CD35) in determining the cellular distribution of opsonized immune complexes between whole blood cells: kinetic analysis of the buffering capacity of erythrocytes. Immunology. 1997 Jan;90(1):129–37. doi: 10.1046/j.1365-2567.1997.00138.x.; Chevalier J, Kazatchkine MD. Distribution in clusters of complement receptor type one (CR1) on human erythrocytes. 1989 Mar 15;142(6):2031–6. doi: 10.4049/jimmunol.142.6.2031.; Müller-Eberhard HJ. Molecular organization and function of the complement system. Annu Rev Biochem. 1988;57():321–47. doi: 10.1146/annurev.bi.57.070188.001541. PMID: 3052276.; Medof ME, Kinoshita T, Nussenzweig V. Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes. J Exp Med. 1984 Nov 01;160(5):1558–78. PMID: 6238120; PMCID: PMC2187498.; Lambris JD, Alsenz J, Schulz TF, Dierich MP. Mapping of the properdin-binding site in the third component of complement. Biochem J. 1984 Jan 01;217(1):323–6. PMID: 6696726; PMCID: PMC1153213.