Regulation of IGF Activity by IGFBP

Holly J, Perks C. The role of insulin-like growth factor binding proteins. Neuroendocrinology. 2006;83(3-4):154–60. doi: 10.1159/000095523. PMID: 17047378.; Zhou R, Diehl D, Hoeflich A, Lahm H, Wolf E. IGF-binding protein-4: biochemical characteristics and functional consequences. J Endocrinol. 2003 Aug;178(2):177–93. doi: 10.1677/joe.0.1780177. PMID: 12904166.; Firth SM, Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev. 2002 Dec;23(6):824–54. doi: 10.1210/er.2001-0033. PMID: 12466191.; Mohan S, Baylink DJ. IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J Endocrinol. 2002 Oct;175(1):19–31. doi: 10.1677/joe.0.1750019. PMID: 12379487.; Hoeflich A, Reisinger R, Lahm H, Kiess W, Blum WF, Kolb HJ, Weber MM, Wolf E. Insulin-like growth factor-binding protein 2 in tumorigenesis: protector or promoter? Cancer Res. 2001 Dec 15;61(24):8601–10. PMID: 11751371.; Schneider MR, Zhou R, Hoeflich A, Krebs O, Schmidt J, Mohan S, Wolf E, Lahm H. Insulin-like Growth Factor-Binding Protein-5 Inhibits Growth and Induces Differentiation of Mouse Osteosarcoma Cells. Biochemical and Biophysical Research Communications. 2001 Oct;288(2):435–42. doi: 10.1006/bbrc.2001.5785.

Metabolites

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
3.4.21.5 thrombin
3.4.21.7 plasmin


Proteins

Protein ID name full name