Synthesis of bile acids and bile salts via 27-hydroxycholesterol

Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Javitt NB. Cholesterol, Hydroxycholesterols, and Bile Acids. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1147–53. doi: 10.1006/bbrc.2001.2013.; Babiker A, Andersson O, Lindblom D, van der Linden J, Wiklund B, Lütjohann D, Diczfalusy U, Björkhem I. Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin. Journal of Lipid Research. 1999 Aug;40(8):1417–25. doi: 10.1016/s0022-2275(20)33383-6.; Björkhem I, Andersson O, Diczfalusy U, Sevastik B, Xiu RJ, Duan C, Lund E. Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages. Proc. Natl. Acad. Sci. U.S.A. 1994 Aug 30;91(18):8592–6. doi: 10.1073/pnas.91.18.8592.

Metabolites



Enzyme

EC Number name full name note
1.1.1.-
1.1.1.181 cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase
1.14.14.139 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase 5beta-cholestane-3alpha,7alpha-diol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (12alpha-hydroxylating)
1.14.15.15 cholestanetriol 26-monooxygenase 5beta-cholestane-3alpha,7alpha,12alpha-triol,adrenodoxin:oxygen oxidoreductase (26-hydroxylating)
1.3.1.3 DELTA4-3-oxosteroid 5beta-reductase 5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase
2.3.1.48 histone acetyltransferase acetyl-CoA:[protein]-L-lysine acetyltransferase


Proteins

Protein ID name full name