Toll-like Receptor Cascades
Kawai T, Akira S. Pathogen recognition with Toll-like receptors. Curr Opin Immunol. 2005 Aug;17(4):338–44. doi: 10.1016/j.coi.2005.02.007. PMID: 15950447.; Heine H, Ulmer AJ. Recognition of bacterial products by toll-like receptors. Chem Immunol Allergy. 2005;86():99–119. doi: 10.1159/000086654. PMID: 15976490.; Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 2005 Jan;17(1):1–14. doi: 10.1093/intimm/dxh186. PMID: 15585605.; Takeda K, Akira S. TLR signaling pathways. Semin Immunol. 2004 Feb;16(1):3–9. doi: 10.1016/j.smim.2003.10.003. PMID: 14751757.; Akira S. Toll-like Receptor Signaling. Journal of Biological Chemistry. 2003 Oct;278(40):38105–8. doi: 10.1074/jbc.r300028200.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 3.6.4.- | |||
| 2.3.2.23 | E2 ubiquitin-conjugating enzyme | S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase | |
| 2.3.2.27 | RING-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type) | |
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) | |
| 2.7.11.10 | IkappaB kinase | ATP:[IkappaB protein] phosphotransferase | |
| 2.7.11.22 | cyclin-dependent kinase | ATP:cyclin phosphotransferase | |
| 2.7.11.24 | mitogen-activated protein kinase | ATP:protein phosphotransferase (MAPKK-activated) | |
| 2.7.11.25 | mitogen-activated protein kinase kinase kinase | ATP:protein phosphotransferase (MAPKKKK-activated) | |
| 3.4.19.12 | ubiquitinyl hydrolase 1 |
Proteins
| Protein ID | name | full name |
|---|