L-proline biosynthesis I

Merrill MJ, Yeh GC, Phang JM. Purified Human Erythrocyte Pyrroline-5-carboxylate Reductase. Journal of Biological Chemistry. 1989 Jun;264(16):9352–8. doi: 10.1016/s0021-9258(18)60538-1.

Metabolites

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Nickel(2+)

Formula: Ni (57.935347)

CAS ID: 14701-22-5

1-pyrroline-5-carboxylate

Formula: C5H6NO2 (112.03985159999999)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.2.1.41 glutamate-5-semialdehyde dehydrogenase L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
1.5.1.2 pyrroline-5-carboxylate reductase L-proline:NAD(P)+ 5-oxidoreductase
2.7.2.11 glutamate 5-kinase ATP:L-glutamate 5-phosphotransferase


Proteins

Protein ID name full name
P07004 proA Gamma-glutamyl phosphate reductase
P0A7B5 proB Glutamate 5-kinase
P0A9L8 proC Pyrroline-5-carboxylate reductase